Loading patent…
AssigneeIndustry-Academic Cooperation Foundation of Sunchon National University
InventorsDong Jo CHANG, Sung-Tae YEE
Estimating the term…
The present invention relates to a method and a structure for verifying the effectiveness of a linker in a ligand-targeted drug delivery system. The structure includes a fluorescent probe, which replaces a drug in the ligand-targeted drug delivery system and is linked to the linker whose effectiveness is to be verified. The fluorescent probe consists of a fluorophore which fluoresces when the linker in the ligand-targeted drug delivery system is cleaved, or consists of a combination of the fluorophore and a spacer. According to the structure and method of the present invention, it is possible to easily and simply confirm whether the linker in the ligand-targeted drug delivery system effectively releases the drug by being stably cleaved in vivo, thereby reducing the development period and cost of ligand-targeted drugs.
A structure for verifying an effectiveness and stability of a linker in a drug delivery system and for verifying an in vivo stability, in vivo cleavability, and in vivo drug release efficiency of the linker in the drug delivery system,
A method for verifying an effectiveness and stability of a linker in a drug delivery system, the method comprising steps of:
Dependencies are inferred from the claim text.