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US 2025/0127871 A1Published application
Methods and compositions for recombinant dengue viruses for vaccine and diagnostic development
AssigneeThe University of North Carolina at Chapel Hill
InventorsRalph Baric, Aravinda de Silva, Ellen Young, Jennifer Munt, Deanna Zhu
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Abstract
The present invention provides compositions and methods of use comprising a chimeric dengue virus E glycoprotein comprising a dengue virus E glycoprotein backbone, which comprises amino acid substitutions that may introduce a domain and/or an epitope that is recognized by an antibody from a dengue virus serotype that is different from the dengue virus serotype of the dengue virus E glycoprotein backbone.
Claims16
A chimeric dengue virus E glycoprotein comprising the amino acid sequence of any one of SEQ ID NOs:
- 1, 2, 3, 4, 5 and/or 6.
5-24. (canceled)
(canceled)
35-52. (canceled)
Dependencies are inferred from the claim text.