Method for producing an antitumoral arenavirus as well as arenavirus mutants
AssigneeAbalos Therapeutics GmbH
InventorsKarl LANG, Cornelia HARDT, Michael BERGERHAUSEN, Hilal BHAT
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Abstract
The invention relates to methods of treating or preventing a tumor.
Claims20
A method of treating or preventing a tumor, the method comprising administering to a patient in need thereof a mutant of lymphocytic choriomeningitis virus, wherein the mutant comprises a nucleic acid encoding a glycoprotein comprising a sequence that is at least 95% identical to residues 59-265 of SEQ ID NO:
- 10 and comprises an Arg 185→Trp amino acid substitution as compared to the wild type glycoprotein sequence set forth in SEQ ID NO:
- 10.
A method of treating or preventing a tumor, the method comprising administering to a patient in need thereof a mutant of lymphocytic choriomeningitis virus, wherein the mutant comprises a nucleic acid encoding a glycoprotein comprising a sequence that is at least 99% identical to residues 59-265 of SEQ ID NO:
- 10 and comprises an Ile181→Met amino acid substitution as compared to the wild type glycoprotein sequence set forth in SEQ ID NO:
- 10.
A method of treating or preventing a tumor, the method comprising administering to a patient in need thereof a virus comprising a glycoprotein protein comprising:
- (i) an amino acid sequence having at least 95% sequence identity to a sequence selected from the group consisting of SEQ ID NO:
- 26, SEQ ID NO:
- 34, SEQ ID NO:
- 42, and SEQ ID NO:
- 50, wherein the protein comprises Arg 185→Trp and Ile 181→Met amino acid substitutions as compared to the wild type glycoprotein sequence set forth in SEQ ID NO:
- 10;
- or
- (ii) an amino acid sequence having at least 95% sequence identity to the sequence of SEQ ID NO:
- 50, wherein the protein comprises an Arg 185→Trp amino acid substitution as compared to the wild type glycoprotein sequence set forth in SEQ ID NO:
- 10.
Dependencies are inferred from the claim text.