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US 2025/0121114 A1Published application
Macroporous hydroxyapatite composition and methods of making such
AssigneeCavix AB
InventorsMichael Wayne Trevino PUJARI-PALMER,, Håkan ENGQVIST
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Abstract
This invention relates to a macroporous cement composition suitable for use as a bone void filler. The macroporous cement composition comprises hydroxyapatite and β-calcium pyrophosphate. The porosity of the composition is 60-80 vol %. The invention also relates to methods of manufacturing such a macroporous cement composition and a putty formulation comprising such a macroporous cement composition.
Claims18
A macroporous cement composition comprising:
- 80-95 wt % hydroxyapatite;
- and,
- β-calcium pyrophosphate, wherein the porosity of the macroporous cement composition is 60-80 vol % as determined using Archimedes method.
A method of manufacturing a macroporous cement composition, wherein the method comprises the steps of:
- mixing α-tricalcium phosphate, β-calcium pyrophosphate, and a sacrificial phase forming a dry powder mix, wherein all components are in solid form;
- mixing the dry powder mix and a liquid forming a paste;
- curing the paste at a temperature above room temperature;
- terminating the chemical reaction associated with the curing after a predetermined time period selected so that a predetermined amount of α-tricalcium phosphate remains unreacted forming a solid cement composition, the predetermined amount being above 1 wt %
- leaching the sacrificial phase from the solid cement composition;
- and
- drying at a temperature above room temperature to form the macroporous cement composition.
4 more elements
Dependencies are inferred from the claim text.