US 2025/0120944 A1 · ANTIBACTERIAL COMPOSITION

Abstract

A compound represented by chemical formula 1, a salt, a stereoisomer, a solvent or a hydrate thereof, an antibacterial composition including the compound, and uses thereof are disclosed. The antibacterial composition is suitable for inhibiting bacterial infections, preventing, alleviating or treating bacterial infectious disease, and for preventing, alleviating or treating inflammation caused by a bacterial infection. The compound specifically binds to p62 protein so as to activate p62, thereby increasing the activity of autophagy, which is inhibited by a bacterial infection, and thus has antibacterial activity against various bacteria, can inhibit bacterial infectivity and has the excellent effect of enabling prevention, alleviation or treatment of bacterial infectious disease and inflammation caused by an infection.

Claims12

Dependent claims

A compound represented by the following Chemical Formula 1, a salt, a stereoisomer, a solvate or a hydrate thereof:

wherein in Chemical Formula 1,
W is phenyl;
Ra, Rb and Rc are each independently hydrogen, halogen,
or —O—(CH2)n1—R1, R1 is unsubstituted phenyl or halogen-substituted phenyl, and n1 is an integer from 1 to 3;
Rd is —CH2—, —O—CH2—CH(CH3)—CH2—, —O—(CH2)˜2—, —O—CH2—CH(OH)—CH2—, —(C═O)— or —N(CH3)—CH2—CH(OH)—CH2—, and n2 is an integer of 1 to 5;
and
Re is —OH or —NH2.

4 more elements

Dependencies are inferred from the claim text.

Facts

Application

18/695,637Filed 25 Nov 2021

Priority

KR 10-2021-012723527 Sep 2021

Published

17 Apr 2025

Term ends

Not estimatedThe source records don’t support an estimate.

Classification25 codes

A61K 31/40
Having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins: having five-membered rings with one nitrogen as the only ring hetero atom,…
A23L 33/10
Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof: using additives
A61K 8/42
Containing nitrogen: amides
A61K 8/4913
With one nitrogen as the only hetero atom: having five membered rings, e.g. pyrrolidone carboxylic acid

Antibacterial composition

Life of this patent

Antibacterial composition

Life of this patent

Abstract

Claims12