Sustained release biodegradable intracanalicular inserts comprising a hydrogel and an active agent
AssigneeOcular Therapeutix, Inc.
InventorsCharles D. Blizzard, Rami El-Hayek, Michael Goldstein, Peter Jarrett, Andrew Vanslette
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Abstract
Provided herein are sustained release biodegradable intracanalicular inserts comprising a hydrogel and an active agent, methods of treating or preventing an ocular disease in a subject in need thereof by administering such inserts as well as methods of manufacturing such inserts.
Claims25
A sustained release biodegradable intracanalicular insert comprising a hydrogel and an active agent, wherein the active agent is in the form of particles, wherein the hydrogel comprises a polymer network comprising polyethylene glycol units having an average molecular weight in the range of from about 2.000 to about 100,000 Daltons, wherein the polymer network comprises multi-arm polymer units comprising 4-8 polyethylene glycol units and cross-linking units comprising an amine and wherein the active agent particles are dispersed within the hydrogel.
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The sustained release biodegradable intracanalicular insert of, wherein the insert contains a non-ionic surfactant.
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Dependencies are inferred from the claim text.