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US 2025/0116680 A1Published application
Assay apparatuses, methods and reagents
AssigneeMeso Scale Technologies, LLC.
InventorCharles M. CLINTON
Life of this patent
Estimating the term…
Abstract
We describe apparatuses, systems, method, reagents, and kits for conducting assays as well as process for their preparation. They are particularly well suited for conducting automated sampling, sample preparation, and analysis in a multi-well plate assay format. For example, they may be used for automated analysis of particulates in air and/or liquid samples derived therefrom in environmental monitoring.
Claims21
1-20. (canceled)
A system, comprising:
- a plurality of sample collection modules configured to receive samples;
- a detection module fluidically coupled to the plurality of sample collection modules and comprising:
- a plate holder configured to support a multi-well assay plate;
- a fluidic manifold configured to receive a sample from at least one of the plurality of sample collection modules;
- a pipettor configured to transfer the sample from the fluidic manifold to a well in the multi-well assay plate;
- and
- a light detector configured to measure luminescence from the well in the multi-well assay plate;
- and
- a computer coupled to the detection module and configured to:
- receive a result of a first test performed on a first sample in the well with a first binding reagent pair;
- and
- responsive to the result, trigger a second test to be performed on a second sample in a second well of the multi-well assay plate with a second binding reagent pair, the second well consecutive with the well, the second test configured to confirm the result of the first test.
9 more elements
A device, comprising:
- a computer configured to:
- receive a result of a first test performed on a first sample in a first well of a multi-well assay plate with a first binding reagent pair;
- based on the result being positive, trigger a second test to be performed on a second sample in a second well with a second binding reagent pair, the second sample matching the first sample and the second well consecutive with the first well, the second test configured to confirm the positive result;
- and
- based on the result being negative, trigger a third test to be performed on a third sample in the second well with the second binding reagent pair, the third sample different from the first sample.
2 more elements
A method, comprising:
- performing a first test of a first sample in a first well of a multi-well assay plate, the first well including a first binding reagent pair;
- determining a result of the first test;
- responsive to the result of the first test being positive, performing a second test of a second sample in a second well of the multi-well assay plate, the second well consecutive with the first well and including a second binding reagent pair;
- and
- responsive to the result of the first test being negative, performing a third test of a third sample in the second well of the multi-well assay plate, the third sample different from the first sample.
2 more elements
Dependencies are inferred from the claim text.