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US 2025/0115955 A1Published application
Compositions and processes for improved mass spectrometry analysis
AssigneeAgena Bioscience, Inc.
InventorThomas BECKER
Life of this patent
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Abstract
The invention provides a novel additive for improved analysis by mass spectrometry. More specifically, ascorbic acid has been found to reduce or eliminate the presence of adducts commonly present in mass spectra. The improved processes and compositions of the invention allow for increased accuracy, sensitivity and throughput for samples analyzed by mass spectrometry.
Claims20
(canceled)
A matrix composition for analysis by mass spectrometry, comprising:
- a matrix material selected from the group consisting of 3-hydroxypicolinic acid (3-HPA), di-ammonium citrate (DAC), or a combination thereof;
- and
- an adduct-reducing additive comprising ascorbic acid, or a salt, tautomer or analog thereof, wherein the molar ratio of the adduct-reducing additive to the matrix material is about 1:20, about 1:19, about 1:18, about 1:17, about 1:16, about 1:15, about 1:14, about 1:13-or about 1:12.
A composition for analysis by mass spectrometry, comprising:
- a nucleic acid analyte;
- a matrix material selected from the group consisting of 3-hydroxypicolinic acid (3-HPA), di-ammonium citrate (DAC), or a combination thereof;
- and
- an adduct-reducing additive comprising ascorbic acid, or a salt, tautomer or analog thereof.
1 more element
Dependencies are inferred from the claim text.