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US 2025/0114775 A1Published application
Process for the preparation of [ru(oac)2(ligand)] catalysts
AssigneeHoffmann-La Roche Inc.
InventorsKurt PUENTENER, Etienne TRACHSEL
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Abstract
The invention comprises a process for the preparation of a [Ru(OAc)2(Ligand)] catalysts of the formula I wherein R1 is C1-6 alkyl and R3 is hydrogen or C1-6 alkyl and R4 is hydrogen or C1-6-alkoxy. [Ru(OAc)2(Ligand)] catalysts are versatile hydrogenation catalysts.
Claims10
A process for the preparation of a [Ru(OAc)2(Ligand)] catalysts of the formula I and its enantiomers,
- wherein R1 is C1-6 alkyl and R3is hydrogen or C1-6 alkyl and R4 is hydrogen or C1-6-alkoxy,
- comprising the conversion of a phosphine precursor of the formula II
- wherein R1, R3 and R4 are as above,
- with [Ru(OAc)2(p-cymene)], wherein Ac stands for acetyl,
- to the [Ru(OAc)2(Ligand)] catalyst of the formula I
- in the presence of a non-polar solvent at a reaction temperature of 40° C. to 110° C.
3 more elements
Dependencies are inferred from the claim text.