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US 2025/0114432 A1Published application
Whey protein micelles against muscle atrophy and sarcopenia
AssigneeSociete des Produits Nestle S.A.
InventorsDenis Breuille, Daniel Ryan Moore, Trent Stellingwerff, Etienne Pouteau, Lionel Jean Rene Bovetto
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Abstract
The present invention relates to whey protein micelles for use in the treatment and/or prevention of a condition linked to a reduced concentration of plasma amino acids in a patient. A further aspect of the invention is a meal replacement comprising whey protein micelles.
Claims10
1:
- A method of inducing hyper-aminoacidemia for a prolonged postprandial period in an individual,
- the method comprising administering to the individual a meal replacement comprising whey protein micelles,
- wherein the prolonged postprandial period of hyper-aminoacidemia is characterized by a peak of the postprandial plasma amino acid concentration more than approximately 90 minutes after administering the meal replacement.
2:
- The method of claim 1, wherein the prolonged postprandial period of hyper-aminoacidemia is characterized by a peak of the postprandial plasma amino acid concentration approximately 120 minutes after administering the meal replacement.
3:
- The method of claim 1, wherein the meal replacement comprises whey protein isolates, hydrolyzed milk proteins, free amino acids or any combination thereof.
4:
- The method of claim 1, wherein the whey protein micelles are present in the meal replacement in an amount of at least 15 wt % of the total dry weight.
5:
- The method of claim 1, wherein the meal replacement comprises 25-50 wt % proteins, 10-15 wt % lipids, 25-50 wt % carbohydrates and 5-10 wt % fibers of total dry weight.
6:
- The method of claim 1, wherein the meal replacement is provided in liquid form.
7:
- The method of claim 1, wherein the meal replacement is provided in a form suitable for enteral tube feeding.
8:
- The method of claim 1, wherein the individual is administered a daily dose of at least 20 g of whey protein micelles.
9:
- The method of claim 1, wherein the prolonged postprandial period of hyper-aminoacidemia is characterized by a peak of the postprandial plasma branched chain amino acid concentration more than approximately 90 minutes after administering the meal replacement.
10:
- The method of claim 9, wherein the prolonged postprandial period of hyper-aminoacidemia is characterized by a peak of the postprandial plasma branched chain amino acid concentration approximately 120 minutes after administering the meal replacement.