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AssigneeMaruzen Pharmaceuticals Co., Ltd.
InventorsRiyo AWA, Yosuke NISHITANI
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Provided is a method for producing a 3-phenylpropionic acid analogue compound represented by Formula (I), the method comprising a step of culturing lactic acid bacteria of genus Weissella using a culture medium that contains 3 mM or more of a cinnamic acid analogue compound represented by Formula (II), the lactic acid bacteria having properties (1a) to (3a) when inoculated to an MRS liquid culture medium containing 3 mM 4-hydroxy-3-methoxycinnamic acid and cultured at 37° C. for 24 hours under an anaerobic condition: (1a) a turbidity of 1.0 or more; (2a) a ratio of reduction to 3-(4-hydroxy-3-methoxyphenyl)propionic acid of 80% or more; and (3a) a ratio of decarboxylation to 4-vinylguaiacol of less than 5%. Also provided are lactic acid bacteria having these properties. The above method and lactic acid bacteria allow a 3-Phenylpropionic acid analogue compound to be efficiently produced.
A method for producing a 3-phenylpropionic acid analogue compound represented by Formula (I) below,
Lactic acid bacteria of genus Weissella having properties (1a) to (3a) below when inoculated to an MRS liquid culture medium containing 3 mM 4-hydroxy-3-methoxycinnamic acid and cultured at 37° C. for 24 hours under an anaerobic condition:
Lactic acid bacteria of genus Weissella having properties (1b) to (3b) below when inoculated to an MRS liquid culture medium containing 5 mM 4-hydroxy-3-methoxycinnamic acid and cultured at 37° C. for 24 hours under an anaerobic condition:
Dependencies are inferred from the claim text.