Sustainable functionalization and methods of use thereof

A method of late-stage functionalization, the method comprising:

• selecting a compound with a nucleophilic moiety;
• reacting the nucleophilic moiety with a protecting group reagent, thereby producing an activated compound;
• subjecting the activated compound to at least one functionalization molecule and at least one hydrolase, wherein the functionalization molecule contains a nucleophilic group, thereby producing a transcarbamoylation reaction product.