A cellular composite
AssigneeAlcyomics LTD
InventorsAnne DICKINSON, Mahid AHMED
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Abstract
The present invention relates to a cellular composite comprising a 3D (three dimensional) cell growth material within which a population of chondrocytes is distributed, and which has a surface that is coated with a population of osteoblasts. The invention also relates to a method of producing said cellular composite and composites produced by the method of the invention. Further the invention relates to an in vitro model for studying healthy or diseased articular cartilage, as well as uses of the composite as an in vitro model. Finally, the invention relates to a method of screening an agent for the treatment or prevention of articular cartilage disease.
Claims25
A method of producing a cellular composite comprising:
- a) distributing a population of mesenchymal stem cells (MSCs) within a three-dimensional (3D) cell growth material and differentiating the MSCs into chondrocytes in a cell culture medium supplemented with a protein of the hyaluronan and proteoglycan binding link protein (HAPLN) family;
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- b) coating a surface of the 3D cell growth material with a population of osteoblasts.
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Dependencies are inferred from the claim text.