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US 2025/0109376 A1Published application
Methods for viral inactivation and other adventitious agents
AssigneeGenentech, Inc.
InventorsMasaru Ken SHIRATORI, Robert David KISS, Hardayal PRASHAD, Raquel IVERSON, Justin BOURRET, Michael KIM, Salim CHARANIYA
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Abstract
The invention provides for methods of viral inactivation using high temperature short time (HTST) treatment and adjustment of various parameters such that generation of precipitate and depositions of precipitate are reduced and/or minimized.
Claims38
A method for inactivating virus or adventitious agents in cell culture media while the media maintains suitability for cell culture, said method comprising (a) subjecting the cell culture media to high temperature short time (HTST) treatment;
- and (b) adjusting one or more parameters selected from the group consisting of pH, calcium level and phosphate level.
Dependencies are inferred from the claim text.