US 2025/0109170 A1 · METHOD FOR MANUFACTURING GANIRELIX

Abstract

In a method for manufacturing ganirelix, a peptide intermediate A represented by Chemical Formula 19 is obtained, a peptide intermediate B represented by Chemical Formula 21 is obtained, and ganirelix represented by Chemical Formula 13 is obtained through a convergent synthesis of the peptide intermediate A and the peptide intermediate B. Ganirelix can be obtained in high purity and high yield, and the commercial mass-production process therefor is feasible, and also, an economical advantage, that is, the reduction in the production costs compared to conventional technologies, is provided. Furthermore, it is possible to obtain a large quantity of Ganirelix more safely than conventional technologies.

Claims18

Dependent claims

A method for manufacturing ganirelix, the method comprising:

obtaining a peptide intermediate A represented by the following Chemical Formula 19;
obtaining a peptide intermediate B represented by the following Chemical Formula 21;
and
obtaining ganirelix represented by the following Chemical Formula 13 through a convergent synthesis of the peptide intermediate A and the peptide intermediate B:
Ac-D-2-Nal-D-Phe(4-Cl)-D-3-Pal-Ser-Tyr-OH [Chemical Formula 19]
H2N-D-hArg(Et)2-Leu-hArg(Et)2-Pro-D-Ala-NH2 [Chemical Formula 21]
Ac-D-2-Nal-D-Phe(4-Cl)-D-3-Pal-Ser-Tyr-D-hArg(Et)2-Leu-Arg(Et)2-Pro-D-Ala-NH2. [Chemical Formula 13]

4 more elements

Dependencies are inferred from the claim text.

Method for manufacturing ganirelix

Life of this patent

Method for manufacturing ganirelix

Life of this patent

Abstract

Claims18