Method for preparing benzylamine derivative through amination of benzylic c-h bond under visible light-induced nickel catalysis

Abstract

A method for preparing a benzylamine derivative through amination of a benzylic C—H bond under visible light-induced nickel catalysis is provided. The method includes: weighing and adding an amination reagent, a ruthenium or iridium photosensitizer, a nickel catalyst, a Lewis acid, and a ligand according to a molar ratio to a reaction vessel; under an inert gas atmosphere, adding a solvent, stirring, adding a benzyl-containing alkylate, and irradiating with a visible light source to allow a full reaction; and conducting separation and purification to obtain the benzylamine derivative. The method involves cheap and easily-available raw materials, and has relatively-extensive substrate applicability. In addition, the method has advantages such as mild reaction conditions, a high yield of a target product, small pollution, and a simple reaction operation and post-treatment, and thus is suitable for industrial production.

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