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US 2025/0109095 A1Published application
Method for preparing oxime derivative
AssigneeSeoul National University R&Db Foundation
InventorsYun Ho LEE, Jin Seong GWAK, Jong Hoon CHOI, Sudakar PADMANABAN
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Abstract
The present disclosure relates to a method for more readily preparing an oxime derivative under mild conditions by using a nitrogen oxide as a NO supply source.
Claims13
A method for preparing an oxime derivative, the method comprising:
- preparing a second compound represented by the following Chemical Formula 2 from a first compound represented by the following Chemical Formula 1,
- wherein the preparing of a second compound uses a Ni-based catalyst represented by the following Chemical Formula 3:
- in Chemical Formula 1 to Chemical Formula 3,
- R1 and R2 are each independently hydrogen;
- an alkyl group having 1 to 6 carbon atoms;
- an alkyl group having 1 to 3 carbon atoms substituted with an unsubstituted or substituted aryl group having 6 to 30 carbon atoms;
- or an unsubstituted or substituted aryl group having 6 to 30 carbon atoms;
- or
- R1 and R2 are linked to each other to form an alicyclic ring having 5 to 12 carbon atoms;
- or an alicyclic ring having 5 to 12 carbon atoms to which an aromatic ring having 6 to 30 carbon atoms bonds;
- and
- X1 and X2 are each independently F;
- Cl;
- Br;
- or I;
- in Chemical Formula 3, iPr represents an iso-propyl group or related substituent;
- and
- in the substituted aryl group having 6 to 30 carbon atoms, the substituent is F;
- Cl;
- Br;
- I;
- an alkyl group having 1 to 3 carbon atoms unsubstituted or substituted with at least one of F, Cl, Br and I;
- an alkoxy group having 1 to 3 carbon atoms unsubstituted or substituted with at least one of F, Cl, Br and I;
- or —CO2Ra, and Ra is an alkyl group having 1 to 3 carbon atoms.
21 more elements
Dependencies are inferred from the claim text.