Methods for treating leakage from a gastrointestinal site
AssigneeEthicon, Inc.
InventorsDegang Zhong, Gerard Llanos, Jianguo Jack Zhou
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Abstract
Disclosed herein are flowable biocompatible sealant compositions in the form of a biodegradable cross-linked gel, comprised of an insoluble agent for preventing infection, and an agent for preventing ischemia, wherein the agent for preventing ischemia is embedded in polymeric microparticles. The composition is characterized in that it releases at least part of said agents in a sustained manner. Uses of the compositions in methods for treating a leakage from a gastrointestinal site are further disclosed.
Claims20
A flowable biocompatible sealant composition in the form of a biodegradable cross-linked gel, the composition comprising an insoluble agent for preventing infection, and an agent for preventing ischemia;
- wherein:
- (a) the agent for preventing ischemia is embedded in polymeric microparticles;
- (b) the composition is characterized by adhesiveness within the range of 0.1 kPa to 100 kPa as measured by a tack test based on ASTM F2258-05, and wherein:
- (c) the composition is characterized in that it releases at least part of said agents in a sustained manner.
A method for preventing and/or treating leakage from an anastomosis site in a subject in need thereof, said method comprising the steps of:
- (a) providing a flowable biocompatible sealant composition capable of forming a biodegradable gel, the composition comprising a therapeutically effective amount of an agent for preventing infection, and an agent for preventing ischemia;
- (b) applying said composition of step (a) to the anastomosis site;
- and
- (c) allowing the composition to form a gel, and to locally release at least part of the two active agents through diffusion and/or upon biodegradation of said gel.
Dependencies are inferred from the claim text.