Methods and kits for preparing radionuclide complexes
AssigneeTheragnostics Limited
InventorsPhilip Blower, Gregory Mullen
Life of this patent
Estimating the term…
Abstract
A method for preparing a complex comprising a radioisotope of gallium for use in radiotherapy or in a medical imaging procedure, said method comprising adding a gallium radioisotope solution obtained directly from a gallium radionuclide generator to a composition comprising a pharmaceutically acceptable buffer and optionally also a pharmaceutically acceptable basic reagent, in amounts sufficient to increase the pH to a level in the range of 3 to 8, wherein the composition further comprises a chelator that is able to chelate radioactive gallium within said pH range and at moderate temperature, said chelator being optionally linked to a biological targeting agent. Kits and compositions for use in the method are also described and claimed.
Claims18
-21. (canceled)
A composition comprising:
- a chelator capable of chelating with a gallium radionuclide at pH 3 to 8 and optionally linked to a biological targeting agent;
- a pharmaceutically acceptable buffer;
- and
- a free radical scavenger, wherein the free radical scavenger is present in an amount of 1-4% w/w of the composition.
A composition consisting essentially of:
- a chelator capable of chelating with a gallium radionuclide at pH 3 to 8 and optionally linked to a biological targeting agent;
- a pharmaceutically acceptable buffer;
- and
- a free radical scavenger, wherein the free radical scavenger is present in an amount of 1-4% w/w of the composition.
Dependencies are inferred from the claim text.