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US 2025/0108064 A1Published application
Phosphate prodrugs of cannabinoids
AssigneeEmory University
InventorsLuke E. Hodson, Nicole Pribut, Stephen F. Traynelis, Dennis C. Liotta
Life of this patent
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Abstract
Phosphate prodrugs of cannabinoids are disclosed herein as are pharmaceutical compositions comprising one or more of the same. Such compounds and compositions are useful for the treatment of diseases, disorders, and/or conditions, including neurological disorders and neuropathic pain.
Claims78
At least one compound chosen from cannabinoid prodrugs of Formula (I):
- and pharmaceutically acceptable salts thereof, wherein
- R1 is chosen from
- groups, wherein
- Z is chosen from divalent C1-18 alkyl and divalent C1-18 haloalkyl groups, wherein the divalent C1-18 alkyl and divalent C1-18 haloalkyl groups are optionally substituted with one or more groups independently chosen from C6-8 aryl, C1-13 heteroaryl, C2-12 heterocyclyl, —OC1-18 alkyl, —SC1-18 is alkyl, —N(T2)C1-18 alkyl, and —N(T2)AA groups, wherein T2 is chosen from H and C1-8 alkyl groups and AA is chosen from amino acid residues and is attached to the nitrogen via its C-terminus carbonyl group;
- X and Y, which may be identical or different, are independently chosen from H, Q, C1-18 alkyl, C1-18 haloalkyl, C6-8 aryl, C1-13 heteroaryl, C7-19 arylalkyl, C2-14 heteroarylalkyl, —(CH2CH2O)nCH3,
- groups, wherein
- each T3, T4, and T5, which may be the same or different, are independently chosen from H and C1-8 alkyl groups,
- each Q is independently chosen from pharmaceutically acceptable cations,
- each n is independently chosen from integers ranging from 1 to 12, and
- each m is independently chosen from integers ranging from 1 to 8;
- and
- R2 is chosen from C1-8 alkyl groups.
9 more elements
2-6. (canceled)
31-46. (canceled)
49-64. (canceled)
69-73. (canceled)
78-80. (canceled)
Dependencies are inferred from the claim text.