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US 2025/0101488 A1Published application
Rapid diagnostic dry reagent test for antibiotic resistance, and methods of use and methods of making thereof
AssigneeBioAmp Diagnostics, Inc.
InventorsTara Renee DeBoer, Angel Resendez
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Abstract
Provided herein are reagent tests that can be used to identify specific types of antibiotic resistant microorganisms in a sample, and methods of use thereof.
Claims34
A solid substrate comprising reagents or components for measuring the presence of a β-lactamase produced by a Gram-negative, Gram-positive or pathogenic beta-lactam resistant bacteria, comprising:
- at least a first pad on the solid substrate which comprises one, two or three components selected from the group consisting of (i) a targeting small molecule probe that is specificity acted on by a β-lactamase;
- (ii) a caged enzyme amplifier;
- and (iii) a chromophore-releasing small molecule indicator that is activated by an uncaged enzyme amplifier.
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Dependencies are inferred from the claim text.