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US 2025/0101067 A1Published application
Modified human cytomegalovirus proteins
AssigneeGlaxosmithkline Biologicals SA
InventorsMarco BIANCUCCI, Newton Muchugu WAHOME
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Abstract
Modified HCMV gB proteins in a pre-fusion conformation, compositions comprising such proteins, and uses thereof.
Claims33
An HCMV gB protein with an amino acid sequence comprising:
- (a) at least one, at least two, at least three, at least four, at least five, or at least six recombinant Cysteine (C) residues;
- and
- (b) a heterologous trimerization domain operably linked c-terminal to the residue corresponding to any one of 698, 699, 700, 701, 702, 703, 704, 705, 706, 707, or 708 of SEQ ID NO:
- 1.
1 more element
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Dependencies are inferred from the claim text.