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US 2025/0101064 A1Published application
Multivalent antibody recruitment molecules
AssigneeMcMaster University
InventorsAnthony Rullo, Yonghong Wan, Benjamin Lake
Life of this patent
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Abstract
The present disclosure relates generally to the field of cancer immunotherapy. More particularly, the present disclosure relates to multivalent antibody recruitment molecules and methods of treating cancer using same.
Claims20
A compound comprising:
- a plurality of target binding domains (TBDs) that bind to two or more different target proteins expressed by a cancer;
- at least one antibody binding domain (ABD) and/or cytotoxic agent;
- and
- a polymer scaffold connecting the plurality of TBDs with the at least one ABD and/or cytotoxic agent.
1 more element
A method of treating cancer in a subject, the method comprising administering an effective amount of a compound to the subject, wherein the compound comprises:
- a plurality of target binding domains (TBDs) that bind to two or more different target proteins expressed by the cancer;
- at least one antibody binding domain (ABD) and/or cytotoxic agent;
- and
- a polymer scaffold connecting the plurality of TBDs with the at least one ABD and/or cytotoxic agent.
1 more element
Dependencies are inferred from the claim text.