Pharmaceutical Compounds, Pharmaceutical compositions, and methods of treating hair loss and other disorders
AssigneeMiralogx LLC
InventorJonnie R. Williams, SR.
Life of this patent
Estimating the term…
Abstract
Pharmaceutical compounds are described for treating hair loss, promoting hair growth, and/or improving the appearance of hair. In one aspect, a method of increasing hair growth includes administering to an individual in need thereof a pharmaceutical composition containing a therapeutically effective amount of a compound or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable vehicle therefor. In another aspect, a method of improving the appearance of hair includes administering to an individual in need thereof a pharmaceutical composition containing a therapeutically effective amount of a compound or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable vehicle therefor.
Claims19
A compound having the structure of Formula (I):
- wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, and R10 are each independently selected from the group consisting of H, OH, protected hydroxyl, alkyl, alkenyl, alkynyl, acyl, aryl, heteroaryl, cycloalkyl, and heterocycle;
- wherein the alkyl, alkenyl, alkynyl or acyl is optionally substituted with one or more substituents independently selected from the group consisting of halogen, —OH, alkyl, —O-alkyl, NRARB, —S-alkyl, —SO-alkyl, —SO2-alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, and heterocycle;
- wherein RA and RB are each independently selected from hydrogen and C1-4 alkyl;
- wherein the aryl or heteroaryl, whether alone or as part of a substituent group, is optionally substituted with one or more substituents independently selected from the group consisting of halogen, —OH, alkyl, —O-alkyl, —COOH, —C(O)—C1-4 alkyl, —C(O)O—C1-4 alkyl, NRCRD, —S-alkyl, —SO-alkyl and —SO2-alkyl;
- wherein RC and RD are each independently selected from hydrogen and C1-4 alkyl;
- or a pharmaceutically acceptable salt or ester thereof.
A compound having the structure of Formula (II):
- wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, and R10 are each independently selected from the group consisting of H, OH, protected hydroxyl, alkyl, alkenyl, alkynyl, acyl, aryl, heteroaryl, cycloalkyl, and heterocycle;
- wherein the alkyl, alkenyl, alkynyl or acyl is optionally substituted with one or more substituents independently selected from the group consisting of halogen, —OH, alkyl, —O-alkyl, NRARB, —S-alkyl, —SO-alkyl, —SO2-alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, and heterocycle;
- wherein RA and RB are each independently selected from hydrogen and C1-4 alkyl;
- wherein the aryl or heteroaryl, whether alone or as part of a substituent group, is optionally substituted with one or more substituents independently selected from the group consisting of halogen, —OH, alkyl, —O-alkyl, —COOH, —C(O) C1-4 alkyl, —C(O)O—C1-4 alkyl, NRCRD, —S-alkyl, —SO-alkyl and —SO2-alkyl;
- wherein RC and RD are each independently selected from hydrogen and C1-4 alkyl;
- or a pharmaceutically acceptable salt or ester thereof.
A compound having a structure selected from the group consisting of:
- or a pharmaceutically acceptable salt, ester, or solvate thereof.
Dependencies are inferred from the claim text.