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US 2025/0100988 A1Published application
Preparation of a compound for the treatment of gout or hyperuricemia
AssigneeArthrosi Therapeutics, Inc.
InventorsShunqi YAN, Litain YEH, Johny Sau-Hoi NG, Shuai PAN, Minghua GAN, Yueming YE
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Abstract
Described herein is the preparation of a compound for treating gout or hyperuricemia and chemical intermediates used in the synthetic process.
Claims34
A process for the preparation of (3,5-dibromo-4-hydroxyphenyl)(2-(1-hydroxyethyl)benzofuran-3-yl-4,5,6,7-d4)methanone (Compound 1):
- comprising contacting a compound with the structure:
- with cesium carbonate in the presence of a solvent.
A process for the preparation of (3,5-dibromo-4-hydroxyphenyl)(2-(1-hydroxyethyl)benzofuran-3-yl-4,5,6,7-d4)methanone (Compound 1), comprising:
- A) the reaction of a compound with the structure:
- with 10% platinum on carbon and deuterium oxide to produce a compound with the structure:
- B) followed by the reaction of the compound with the structure:
- with sodium nitrite, potassium iodide, and toluenesulfonic acid to produce a compound with the structure:
- C) the reaction of a compound with the structure:
- with 4-methoxybenzyl chloride and potassium carbonate to produce a compound with the structure:
- D) the reaction of the compound with the structure:
- with benzoyl chloride and pyridine to produce a compound with the structure:
- E) followed by the reaction of the compounds with the structures:
- with lithium diisopropylamide to produce a compound with the structure:
- F) followed by the reaction of the compound with the structure:
- with sodium bicarbonate, potassium bromide, (2,2,6,6-tetramethylpiperidin-1-yl)oxyl (TEMPO), and sodium hypochlorite to produce a compound with the structure:
- G) followed by the reaction of the compounds with the structures:
- and potassium phosphate, followed by contact with trifluoroacetic acid to produce a compound with the structure:
- H) followed by the reaction of the compound with the structure:
- with potassium carbonate and Pd(dppf)Cl2 to produce a compound with the structure:
- I) followed by the reaction of the compound with the structure:
- with cesium carbonate to produce a compound with the structure:
15 more elements
A compound having a structure selected from:
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.