NON-ATP/CATALYTIC SITE p38 MITOGEN ACTIVATED PROTEIN KINASE INHIBITORS

A compound of the formula:

• or a pharmaceutically acceptable salt thereof, wherein,
• L1 is selected from —CH2—, —C(CH3)2—, and —C(CH2CH2)—;
• L2 is selected from —NH—SO2—, —NHCH2—, —CH2NH—, —NHCO—, —CONH, and —SO2NH—;
• and
• each of R1a and R2a is independently selected from hydrogen, C1-10 alkyl, and C1-10 alkyl substituted by one or more of substituents which are independently hydroxy, halo, cyano, trifluoromethyl, trifluoromethoxy, nitro, trimethylsilanyl, —ORa, —SRa, —S(O)tRa (wherein t is 1 or 2), —OC(O)—Ra, —N(Ra)2, —C(O)Ra, —C(O)ORa, —OC(O)N(Ra)2, —C(O)N(Ra)2, —N(Ra)C(O)ORa, —N(Ra)C(O)Ra, —N(Ra)C(O)N(Ra)2, —N(Ra)C(NRa)N(Ra)2, —N(Ra)S(O)tRa (wherein t is 1 or 2), —S(O)tRa (wherein t is 1 or 2), —S(O)tORa (wherein t is 1 or 2), —S(O)tN(Ra)2 (wherein t is 1 or 2), or —PO(ORa)2 wherein each Ra is independently hydrogen and C1-3 alkyl;
• and
• —NR1R2 is selected from:
• wherein,
• R7 is selected from hydrogen, OH, C1-10 alkyl, and substituted C1-10 alkyl;
• and
• Ar2 is a heteroaryl.