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US 2025/0100977 A1Published application
Mercaptopyrimidine compounds that inhibit nonhomologous end joining and methods thereof
AssigneesIndian Institute of Science, University of Mysore
InventorsSathees C RAGHAVAN, Ujjayinee RAY, Vindya K GOPINATHA, Shivangi SHARMA, Kempegowda MANTELINGU, Kanchugarakoppal S RANGAPPA, Laijau GOYARY
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Abstract
The present disclosure provides a compound of Formula I, its stereoisomers, intermediates, and pharmaceutically acceptable salts thereof, capable of inhibiting DNA Ligase IV enzyme activity and nonhomologous end joining (NHEJ). The present disclosure also provides a process for preparing the compounds of Formula I and methods thereof.
Claims22
A compound of Formula I,
- its stereoisomers, intermediates, and pharmaceutically acceptable salts thereof,
- wherein R is selected from a group consisting of substituted monocyclic C6-10 aryl, C1-12 alkyl, bicyclic C8-12 aryl, C3-10heteroaryl, C3-10 cycloalkyl, and C3-10heterocyclyl;
- wherein bicyclic C8-12 aryl, C1-12 alkyl, C3-10heteroaryl, C3-10 cycloalkyl, and C3-10heterocyclyl are optionally substituted.
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Dependencies are inferred from the claim text.