Clock activators and uses thereof

A compound, having the formula:

• wherein
• XA is —Cl, —Br, —I, or —F;
• L2 is a bond;
• R4 is unsubstituted C4-C20 alkenyl;
• R1 is independently halogen, —CX13, —CHX12, —CH2X1, —OCX13, —OCH2X1,
• —OCHX12, —CN, —SOn1R1D, —SOv1NR1AR1B, —NR1CNR1AR1B, —ONR1AR1B, —NR1CC(O)NR1AR1B,
• —N(O)m1, —NR1AR1B, —C(O)R1C, —C(O)OR1C, —OC(O)R1C, —OC(O)OR1C, —C(O)NR1AR1B,
• —OC(O)NR1AR1B, —OR1D, —SR1D, —NR1ASO2R1D, —NR1AC(O)R1C, —NR1AC(O)OR1C, —NR1AOR1C,
• —N3, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R1A, R1B, R1C, and R1D are independently hydrogen, —CCl3, —CBr3, —CF3, —Cl3,
• —CHCl2, —CHBr2, —CHF2, —CHI2, —CH2Cl, —CH2Br, —CH2F, —CH2I, —CN, —OH, —NH2, —COOH,
• —CONH2, —OCCl3, —OCF3, —OCBr3, —OCI3, —OCHCl2, —OCHBr2, —OCHI2, —OCHF2, —OCH2Cl,
• —OCH2Br, —OCH2I, —OCH2F, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R1A and R1B substituents bonded to the same nitrogen atom may optionally be joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl;
• z1 is an integer from 0 to 3;
• each X1 is independently —Cl, —Br, —I, or —F;
• n1 is independently an integer from 0 to 4;
• and
• m1 and v1 are independently 1 or 2.

A pharmaceutical composition comprising a pharmaceutically acceptable excipient and a compound, or a pharmaceutically acceptable salt thereof, having the formula:

• wherein
• XA and XB are independently —Cl, —Br, —I, or —F;
• L1 is a bond, —C(O)—, —C(O)O—, —OC(O)—, —O—, —S—, —NR10—, —C(O)NR10—,
• —NR10C(O)—, —NR10C(O)O—, —OC(O)NR10—, —NR10C(O)NR10—, —NR10C(NH)NR10—, —S(O)2—,
• —NR10S(O)2—, —S(O)2NR10—, substituted or unsubstituted alkylene, substituted or unsubstituted heteroalkylene, substituted or unsubstituted cycloalkylene, substituted or unsubstituted heterocycloalkylene, substituted or unsubstituted arylene, or substituted or unsubstituted heteroarylene;
• L2 is a bond, —C(O)—, —C(O)O—, —OC(O)—, —O—, —S—, —NR20—, —C(O)NR20—,
• —NR20C(O)—, —NR20C(O)O—, —OC(O)NR20—, —NR20C(O)NR20—, —NR20C(NH)NR20—, —S(O)2—,
• —NR20S(O)2—, —S(O)2NR20—, substituted or unsubstituted alkylene, substituted or unsubstituted heteroalkylene, substituted or unsubstituted cycloalkylene, substituted or unsubstituted heterocycloalkylene, substituted or unsubstituted arylene, or substituted or unsubstituted heteroarylene;
• L3 is a bond, —C(O)—, —C(O)O—, —OC(O)—, —O—, —S—, —NR30—, —C(O)NR30—,
• —NR30C(O)—, —NR30C(O)O—, —OC(O)NR30—, —NR30C(O)NR30—, —NR30C(NH)NR30—, —S(O)2—,
• —NR30S(O)2—, —S(O)2NR30—, substituted or unsubstituted alkylene, substituted or unsubstituted heteroalkylene, substituted or unsubstituted cycloalkylene, substituted or unsubstituted heterocycloalkylene, substituted or unsubstituted arylene, or substituted or unsubstituted heteroarylene;
• R1 is independently halogen, —CX13, —CHX12, —CH2X1, —OCX13, —OCH2X1,
• —OCHX12, —CN, —SOn1R1D, —SOv1NR1AR1B, —NR1CNR1AR1B, —ONR1AR1B, —NR1CC(O)NR1AR1B,
• —N(O)m1, —NR1AR1B, —C(O)R1C, —C(O)OR1C, —OC(O)R1C, —OC(O)OR1C, —C(O)NR1AR1B,
• —OC(O)NR1AR1B, —OR1D, —SR1D, —NR1ASO2R1D, —NR1AC(O)R1C, —NR1AC(O)OR1C, —NR1AOR1C,
• —N3, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R2 is hydrogen, halogen, —CX23, —CHX22, —CH2X2, —OCX23, —OCH2X2, —OCHX22,
• —CN, —SOn2R2D, —SOv2NR2AR2B, —NR2CNR2AR2B, —ONR2AR2B, —NR2CC(O)NR2AR2B, —N(O)m2,
• —NR2AR2B, —C(O)R2C, —C(O)OR2C, —OC(O)R2C, —OC(O)OR2C, —C(O)NR2AR2B, —OC(O)NR2AR2B,
• —OR2D, —SR2D, —NR2ASO2R2D, —NR2AC(O)R2C, —NR2AC(O)OR2C, —NR2AOR2C, —N3, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R3 is hydrogen, —CCl3, —CBr3, —CF3, —CI3, —CHCl2, —CHBr2, —CHF2, —CHI2, —CH2Cl, —CH2Br, —CH2F, —CH2I, —CN, —OH, —NH2, —COOH, —CONH2, —OCCl3, —OCF3, —OCBr3, —OCI3,
• —OCHCl2, —OCHBr2, —OCHI2, —OCHF2, —OCH2Cl, —OCH2Br, —OCH2I, —OCH2F, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R2 and R3 substituents may optionally be joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl;
• R4 is hydrogen, halogen, —CX43, —CHX42, —CH2X4, —OCX43, —OCH2X4, —OCHX42,
• —CN, —SOn4R4D, —SOv4NR4AR4B, —NR4CNR4AR4B, —ONR4AR4B, —NR4CC(O)NR4AR4B, —N(O)m4,
• —NR4AR4B, —C(O)R4C, —C(O)OR4C, —OC(O)R4C, —OC(O)OR4C, —C(O)NR4AR4B, —OC(O)NR4AR4B,
• —OR4D, —SR4D, —NR4ASO2R4D, —NR4AC(O)R4C, —NR4AC(O)OR4C, —NR4AOR4C, —N3, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R5 is hydrogen, —CCl3, —CBr3, —CF3, —CI3, —CHCl2, —CHBr2, —CHF2, —CHI2, —CH2Cl,
• —CH2Br, —CH2F, —CH2I, —CN, —OH, —NH2, —COOH, —CONH2, —OCCl3, —OCF3, —OCBr3, —OCI3,
• —OCHCl2, —OCHBr2, —OCHI2, —OCHF2, —OCH2Cl, —OCH2Br, —OCH2I, —OCH2F, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R6 is hydrogen, halogen, —CX63, —CHX62, —CH2X6, —OCX63, —OCH2X6, —OCHX62,
• —CN, —SOn6R6D, —SOv6NR6AR6B, —NR6CNR6AR6B, —ONR6AR6B, —NR6CC(O)NR6AR6B, —N(O)m6,
• —NR6AR6B, —C(O)R6C, —C(O)OR6C, —OC(O)R6C, —OC(O)OR6C, —C(O)NR6AR6B, —OC(O)NR6AR6B,
• —OR6D, —SR6D, —NR6ASO2R6D, —NR6AC(O)R6C, —NR6AC(O)OR6C, —NR6AOR6C, —N3, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R5 and R6 substituents may optionally be joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl;
• R7 is independently halogen, —CX73, —CHX72, —CH2X7, —OCX73, —OCH2X7,
• —OCHX72, —CN, —SOn7R7D, —SOv7NR7AR7B, —NR7CNR7AR7B, —ONR7AR7B, —NR7CC(O)NR7AR7B,
• —N(O)m7, —NR7AR7B, —C(O)R7C, —C(O)OR7C, —OC(O)R7C, —OC(O)OR7C, —C(O)NR7AR7B,
• —OC(O)NR7AR7B, —OR7D, —SR7D, —NR7ASO2R7D, —NR7AC(O)R7C, —NR7AC(O)OR7C, —NR7AOR7C,
• —N3, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• each R10, R20, and R30 is independently hydrogen, —CCl3, —CBr3, —CF3, —Cl3,
• —CH2Cl, —CH2Br, —CH2F, —CH2I, —CHCl2, —CHBr2, —CHF2, —CHI2, —CN, —OH, —NH2, —COOH,
• —CONH2, —OCCl3, —OCBr3, —OCF3, —OCI3, —OCH2Cl, —OCH2Br, —OCH2F, —OCH2I, —OCHCl2,
• —OCHBr2, —OCHF2, —OCHI2, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R1A, R1BR1C, R1D, R2A, R2B, R2C, R2D, R4A, R4B, R4C, R4D, R6A, R6B, R6C, R6D, R7A, R7B, R7C, and R7D are independently hydrogen, —CCl3, —CBr3, —CF3, —CI3, —CHCl2, —CHBr2,
• —CHF2, —CHI2, —CH2Cl, —CH2Br, —CH2F, —CH2I, —CN, —OH, —NH2, —COOH, —CONH2, —OCCl3,
• —OCF3, —OCBr3, —OCI3, —OCHCl2, —OCHBr2, —OCHI2, —OCHF2, —OCH2Cl, —OCH2Br, —OCH2I,
• —OCH2F, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R1A and R1B substituents bonded to the same nitrogen atom may optionally be joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl;
• R2A and R2B substituents bonded to the same nitrogen atom may optionally be joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl;
• R4A and R4B substituents bonded to the same nitrogen atom may optionally be joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl;
• R6A and R6B substituents bonded to the same nitrogen atom may optionally be joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl;
• R7A and R7B substituents bonded to the same nitrogen atom may optionally be joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl;
• z1 is an integer from 0 to 3;
• z7 is an integer from 0 to 3;
• each X1, X2, X4, X6, and X7 is independently —Cl, —Br, —I, or —F;
• n1, n2, n4, n6, and n7 are independently an integer from 0 to 4;
• and
• m1, m2, m4, m6, m7, v1, v2, v4, v6, and v7 are independently 1 or 2.