Active immunization for reducing osteoarthritic, neuropathic, and cancer pain
AssigneeInstitut Pasteur de Montevideo
InventorsLuis Hector BARBEITO ERBA, Emiliano TRIAS TEJERIA, Valentina Varela PIEDRA BUENA, Gabriel Gaston SEMIGLIA REPETTO, Andrea Elena FILOMENO ANDRIOLO, Carolina SEMIGLIA ALVAREZ
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Abstract
A recombinant fusion protein used for active immunization or vaccine in the treatment of pain in a subject and a method thereof. The recombinant fusion protein includes: a nerve growth factor (NGF); and substance P (SP) or a calcitonin gene-related peptide (CGRP). The pain can be associated with osteoarthritis (OA), neurogenic inflammation, neuropathy, rheumatoid arthritis, post-surgery or cancer. The invention is particularly useful for treating OA pain in animals.
Claims33
An immunogenic recombinant fusion protein comprising:
- at least one immunogenic fragment derived from a nerve growth factor (NGF);
- and
- at least one immunogenic fragment derived from substance P (SP) or calcitonin gene-related peptide (CGRP)
- wherein the recombinant fusion protein is capable of eliciting a protective immune response against a nociceptive pain by eliciting the production of neutralizing antibodies.
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Dependencies are inferred from the claim text.