Prevention or treatment of cardiovascular diseases with high penetration prodrugs of aspirin and other nsaids

A method of preventing or treating cardiovascular disease or condition in a subject, comprising topically administering a pharmaceutical composition comprising a compound of Formula (I), a stereoisomer thereof, or a pharmaceutically acceptable salt thereof to the subject:

• wherein:
• Rx is selected from H, 2,4-difluorophenyl, substituted and unsubstituted alkyl, substituted and unsubstituted cycloalkyl, substituted and unsubstituted heterocyclyl, substituted and unsubstituted alkoxy, substituted and unsubstituted alkenyl, substituted and unsubstituted alkynyl, substituted and unsubstituted aryl, and substituted and unsubstituted heteroaryl;
• Ry is selected from H, substituted and unsubstituted alkylcarbonyl, substituted and unsubstituted alkoxycarbonyl, substituted and unsubstituted benzoyl, substituted and unsubstituted alkyl, substituted and unsubstituted cycloalkyl, substituted and unsubstituted heterocyclyl, substituted and unsubstituted alkoxy, substituted and unsubstituted alkenyl, substituted and unsubstituted alkynyl, substituted and unsubstituted aryl, and substituted and unsubstituted heteroaryl;
• L1 is a linker selected from O, S, NH, O—CH(L2), O—(CH2)n, O—CH(L2)—O—C(═O), O—CH(L2)-O, S—CH(L2)-O, and —O—C(═O)—, wherein n is an integer selected from 1 to 6;
• L2 at each occurrence is independently selected from H, substituted and unsubstituted alkyl, substituted and unsubstituted cycloalkyl, substituted and unsubstituted heterocyclyl, substituted and unsubstituted aryl, substituted and unsubstituted heteroaryl, substituted and unsubstituted alkoxy, substituted and unsubstituted alkylthio, and substituted and unsubstituted alkylamino;
• T is a transportational unit comprising a protonatable amine group.