Compositions, methods, and development of arid4b inhibitors
AssigneesUniversity of Kentucky Research Foundation, The George Washington University
InventorsSamuel Ofori, Samuel Gorman Awuah, Ray-Chang Wu, Mei-Yi Wu
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Abstract
The present disclosure generally relates to classes of compounds that bind the chromo-barrel domain of AT-rich interactive domain 4B (ARID4B). In some aspects, the compounds are of the Formula (II) as described herein, or a diamine composite thereof as set forth in Formula III herein. In some aspects, the compound is selected from compounds 1a, 1b, 1c, 1d, 1e, 2a, 2b, 2c, 2d, 2e, 2f, 2g, 2h, 2i, 2j, (as described herein) or combinations thereof. The present disclosure further considers administration of the compounds to target ARID4B in cells and for the treatment of cancerous breast tissue cells.
Claims18
An ARD150 derivative compound comprising the structure as set forth in Formula (II),
- or a salt thereof
- wherein the spacer is null or —OCH2;
- R1 is null, H, or CH3;
- R2 is H or CH3;
- and,
- R0 is selected from:
- or a piperazine with the nitrogen of the depicted amide.
Dependencies are inferred from the claim text.