Trans-4-hydroxycyclohexyl phenyl amide mitofusin activators and methods of use thereof
AssigneeMitochondria In Motion, Inc.
InventorGerald W. DORN, II
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Abstract
Compounds and compositions including stereoisomers of 6-phenylhexanamide derivative small molecule mitofusin activators are described. In particular, mitofusin activators comprising derivatives of (trans-4-hydroxycyclohexyl)-6-phenylhexanamide, which are useful for treating diseases or disorders associated with a mitochondria-associated disease, disorder, or condition such as diseases or disorders associated with mitofusin-1 (MFN1) and/or mitofusin-2 (MFN2), or mitochondrial dysfunction, are described. Methods of treatment and pharmaceutical formulations are also described.
Claims9
A method comprising:
- administering a therapeutically effective amount of a composition comprising one or more of a mitofusin activator or a pharmaceutically acceptable salt thereof to a subject having or suspected of having a mitochondria-associated disease, disorder or condition, the mitofusin activator having a structure represented by a formula selected from the group consisting of
A composition comprising:
- a mitofusin activator or a pharmacologically acceptable salt thereof, the mitofusin activator having a structure represented by a formula selected from the group consisting of
Dependencies are inferred from the claim text.