Thioester cationic lipids
AssigneeTranslate Bio, Inc.
InventorsYi Zhang, Shrirang Karve, Frank DeRosa, Michael Heartlein
Life of this patent
Estimating the term…
Abstract
Disclosed are cationic lipids which are compounds of Formula (I), (II), (III), (IV), (V), or (VI). Cationic lipids provided herein can be useful for delivery and expression of mRNA and encoded protein, e.g., as a component of liposomal delivery vehicle, and accordingly can be useful for treating various diseases, disorders and conditions, such as those associated with deficiency of one or more proteins.
Claims26
1-31. (canceled)
A cationic lipid having a structure according to Formula (II),
- wherein
- each a is independently an integer of 1-5;
- b is independently an integer of 0-6;
- each XA1 and XB1 is independently O or S;
- each LA and LB is independently C1-C10 alkylene;
- C2-C10 alkenylene;
- or C2-C10 alkynylene;
- each XA2 is independently NH, NRA, CH2, or CHRA;
- XB2 is independently NH, NRB, CH2, or CHRB;
- and
- each RA and RB is independently C6-C30 alkyl, C6-C30 alkenyl, or C6-C30 alkynyl.
33-54. (canceled)
A cationic lipid having a structure according to Formula (III):
- wherein
- each a is independently an integer of 0-6;
- each XA1 is independently O or S;
- each LA is independently C1-C10 alkylene;
- C2-C10 alkenylene;
- or C2-C10 alkynylene;
- XA is independently NH, NRA, CH2, or CHRA;
- and
- each RA is independently 6-C30 alkyl, G6-C30 alkenyl, or 6-C30 alkynyl.
57-74. (canceled)
A cationic lipid having a structure according to Formula (IV),
- wherein
- R1 is hydrogen, C1-C30 alkyl, C2-C30 alkenyl, or C2-C30 alkynyl;
- each a and b is an integer of 0-6;
- each XA1 and XB1 is independently O or S;
- each LA and LB is independently C1-C10 alkylene;
- C2-C10 alkenylene;
- or C2-C10 alkynylene;
- LC is independently —C(O)— or —(CH2)b—;
- XA2 is independently NH, NRA, CH2, or CHRA;
- XB2 is independently NH, NRB, CH2, or CHRB;
- and
- each RA and RB is independently C6-C30 alkyl, C6-C30 alkenyl, or C6-C30 alkynyl.
77-107. (canceled)
109-120. (canceled)
122-125. (canceled)
127-132. (canceled)
133-139. (canceled)
Dependencies are inferred from the claim text.