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US 2025/0093340 A1Published application
Antibodies to methotrexate and uses thereof
OwnerJohnny Valdez, Byung Sook Moon +2inventors
InventorsJohnny Valdez, Byung Sook Moon, Rajendra Singh, Jacqueline Nguyen-Choi
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Abstract
Disclosed herein are antibodies that specifically bind to a methotrexate analyte. Such antibodies can be used to detect a methotrexate analyte in a sample, such as in a homogeneous enzyme immunoassay method. Hapten structures to elicit such antibodies and conjugates useful in immunoassays are also described.
Claims19
A compound of Formula 1:
- wherein:
- R1 is —Y—Z;
- Y is a linking group;
- and
- Z is selected from the group consisting of hydrogen, OH, SH, S-acyl, O-alkyl, halogen, NH2, epoxy, maleimidyl, haloacetamide, carboxyl, activated carboxyl, N3 and alkenean immunogenic carrier, a protein, a label, and a solid support,
- and salts thereof.
3 more elements
-13. (canceled)
An antibody that specifically binds to the compound of Formula 1:
- wherein:
- R1 is —Y—Z;
- Y is a linking group;
- and
- Z is selected from the group consisting of hydrogen, OH, SH, S-acyl, O-alkyl, halogen, NH2, epoxy, maleimidyl, haloacetamide, carboxyl, activated carboxyl, N3 and alkenean immunogenic carrier, a protein, a label, and a solid support,
- and salts thereof.
3 more elements
Dependencies are inferred from the claim text.