# US 2025/0093271 A1 · Thermal drift calibrated microcavities and systems using optical frequency domain reflectometry > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2025/0093271 A1 - Document ID: US20250093271A1 - Status: Published application - Kind: A1 - Application number: 18/832,453 - Filed: 2023-01-24 - Published: 2025-03-20 - Earliest claimed: 2022-01-24 - Assignees: Arizona Board of Regents on Behalf of the University of Arizona - Applicants: Arizona Board of Regents on Behalf of the University of Arizona - Inventors: Judith SU; Cheng LI - Web page: https://patentgrep.com/patent/US20250093271A1 ## CPC - G01N 21/7746: {the waveguide coupled to a cavity resonator} - G01N 15/0205: by optical means - G01N 15/06: Investigating concentration of particle suspensions (by weighing G01N5/00; investigating sedimentation of particle suspensions G01N15/04; investigating individual particles G01N15/10) - G01N 15/1434: Optical arrangements - G01N 15/01: specially adapted for biological cells, e.g. blood cells (investigating sedimentation of particle suspensions in blood G01N15/05) - G01N 15/075: by optical means - G01N 2015/0687: {in solutions, e.g. non volatile residue} - G01N 2015/1006: {for cytology} - G01N 2015/1493: {Particle size} - G01N 2201/06113: Coherent sources; lasers - G01N 2201/1211: for temperature - G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q) ## Abstract A temperature-corrected biochemical sensor includes an optical resonator disposed proximate a single-mode optical fiber, the optical resonator being optically coupled to the optical fiber to receive optical whispering-gallery output light; a sensor detection system arranged to receive and detect the optical whispering-gallery output light to provide sensor signals; a temperature-correcting optical system to provide a reference beam of light to be combined at least partially coherently with a return light from the resonator to provide an interference light and convert, the interference light to temperature-correction signals; a data storage device comprising temperature calibration data for at least the optical fiber and the optical resonator; and a data processing system to calculate at least one physical property of a particle in contact with the optical resonator using the sensor signals such that the calculated physical property is temperature corrected using the temperature calibration data and the temperature-correction signals. ## Claims ### Claim 1 A temperature-corrected biochemical sensor, comprising: a sensor optical source; an optical coupler arranged to receive sensor light from said sensor optical source; a single-mode optical fiber optically coupled to said optical coupler to receive said sensor light; an optical resonator disposed proximate said single-mode optical fiber, said optical resonator having an optical whispering-gallery mode and being optically coupled to said single-mode optical fiber through an evanescent field to excite said optical whispering-gallery mode and to receive optical whispering-gallery output light; a sensor detection system arranged to receive and detect said optical whispering-gallery output light from said single-mode optical fiber to provide sensor signals; a temperature-correcting optical system arranged to couple temperature-correcting light into said optical coupler to thereby be coupled into said single-mode optical fiber and further arranged to receive return light from said optical coupler comprising temperature-correcting light being at least one of scattered or reflected back to said temperature-correcting optical system, wherein said temperature-correcting optical system is further configured to provide a reference beam of light to be combined at least partially coherently with said return light to provide an interference light, and wherein said temperature-correcting optical system further comprises a detector system arranged to detect said interference light to provide temperature-correction signals; a data storage device comprising temperature calibration data for at least said single-mode optical fiber and said optical resonator; and a data processing system configured to: communicate with said data storage device to receive said temperature calibration data, communicate with said sensor detection system to receive said sensor signals, and communicate with said temperature-correcting optical system to receive said temperature-correction signals, wherein said data processing system is further configured to calculate at least one physical property of a particle in contact with said optical resonator using said sensor signals such that said calculated at least one physical property is temperature corrected using said temperature calibration data and said temperature-correction signals. ### Claim 2 (depends on 1) The temperature-corrected biochemical sensor according to claim 1, wherein said optical coupler comprises a wavelength division multiplexer (WDM). ### Claim 3 (depends on 1) The temperature-corrected biochemical sensor according to claim 1, wherein said temperature-correcting optical system comprises: a tunable laser optically coupled to an optical splitter to split light between said temperature-correcting light and said reference beam of light, and an optical circulator arranged to direct said temperature-correcting light to said optical coupler and to direct said return light to an optical combiner to combine said return light with said reference beam of light. ### Claim 4 (depends on 3) The temperature-corrected biochemical sensor according to claim 3, wherein said sensor optical source and said tunable laser of said temperature-correcting optical system transmit in different wavelength bands. ### Claim 5 (depends on 1) The temperature-corrected biochemical sensor according to claim 1, wherein said data processing system is further configured to perform a Fourier transform of said temperature-correction signals and perform a correlation with said temperature calibration data to obtain a temperature correction of said at least one physical property of said particle in contact with said optical resonator. ### Claim 6 (depends on 1) The temperature-corrected biochemical sensor according to claim 1, wherein said sensor optical source is frequency locked to a resonance frequency of said optical resonator and provides light sufficiently intense to provide four-wave mixing while being coupled with said optical resonator to generate a comb spectrum received by said optical coupler, and wherein said comb spectrum provides characteristic changes of the optical resonator at the resonance frequency in the presence of said particle in contact with said optical resonator to provide detection and characterization of said particle. ### Claim 7 (depends on 3) The temperature-corrected biochemical sensor according to claim 3, further comprising a phase-noise correction system arranged to receive a portion of light from said a tunable laser split off prior to said optical splitter that split lights between said temperature-correcting light and said reference beam of light to provide phase-noise correction light, said phase-noise correction system comprising: an optical splitter to split said phase-noise correction light to a first optical path and a second optical path, an optical delay line arranged in said second optical path, an optical combiner arranged to combine light from both said first and second optical paths after light in said second optical path passes through said optical delay line, and an optical detector arranged to detect light from said optical combiner. ### Claim 8 (depends on 1) The temperature-corrected biochemical sensor according to claim 1, wherein said optical resonator is at least one of a disk, a goblet, a sphere, a ring, or a toroidal optical resonator. ### Claim 9 (depends on 1) The temperature-corrected biochemical sensor according to claim 1, wherein a diameter of a resonance portion of said optical resonator is between 5 μm and 100 mm. ### Claim 10 (depends on 1) The temperature-corrected biochemical sensor according to claim 1, wherein said particle is at least one of a molecule, a virus, a portion of a virus, a biological cell, a portion of a biological cell, a microorganism, a portion of a microorganism, a chemical compound, a protein, or a portion of a protein. ### Claim 11 (depends on 1) The temperature-corrected biochemical sensor according to claim 1, wherein the single-mode optical fiber has a taper so as to enhance coupling of light from the single-mode optical fiber to the optical resonator. ### Claim 12 A data processing system having one or more processors, a memory, and a storage device in communication with the one or more processors, wherein the one or more processors is configured to execute instructions stored in the memory and the storage device to perform a method for determining at least one physical property of a particle in contact with an optical resonator, the method comprising: receiving, by the one or more processors, temperature calibration data from said storage device, for at least a single-mode optical fiber and said optical resonator, said single-mode optical fiber being disposed in proximity of said optical resonator, said single-mode optical fiber being optically coupled to an optical coupler arranged to receive sensor light from a sensor optical source, said optical resonator having an optical whispering-gallery mode and being optically coupled to said single-mode optical fiber through an evanescent field to excite said optical whispering-gallery mode and to receive optical whispering-gallery output light; receiving, by the one or more processors, sensor signals from a sensor detection system arranged to receive and detect said optical whispering-gallery output light from said single-mode optical fiber; receiving, by the one or more processors, temperature-correction signals from a temperature-correcting optical system arranged to couple temperature-correcting light into said optical coupler to thereby be coupled into said single-mode optical fiber and further arranged to receive return light from said optical coupler comprising temperature-correcting light being at least one of scattered or reflected back to said temperature-correcting optical system, said temperature-correcting optical system being further configured to provide a reference beam of light to be combined at least partially coherently with said return light to provide an interference light, said temperature-correcting optical system further comprising a detector system arranged to detect said interference light to provide said temperature-correction signals; determining, by the one or more processors, at least one physical property of the particle in contact with said optical resonator using said sensor signals; and correcting said at least one physical property in temperature using said temperature calibration data and said temperature-correction signals. ### Claim 13 (depends on 12) The data processing system according to claim 12, further comprising: performing, by the one or more processors, a Fourier transform of said temperature-correction signals; and performing, by the one or more processors, a correlation with said temperature calibration data to obtain a temperature correction of said at least one physical property of said particle in contact with said optical resonator. ### Claim 14 A method for determining at least one physical property of a particle in contact with an optical resonator, the method comprising: receiving, by one or more computer processors, temperature calibration data from a storage device, for at least a single-mode optical fiber and said optical resonator, said single-mode optical fiber being disposed in proximity of said optical resonator, said single-mode optical fiber being optically coupled to an optical coupler arranged to receive sensor light from a sensor optical source, said optical resonator having an optical whispering-gallery mode and being optically coupled to said single-mode optical fiber through an evanescent field to excite said optical whispering-gallery mode and to receive optical whispering-gallery output light; receiving, by the one or more computer processors, sensor signals from a sensor detection system arranged to receive and detect said optical whispering-gallery output light from said single-mode optical fiber; receiving, by the one or more computer processors, temperature-correction signals from a temperature-correcting optical system arranged to couple temperature-correcting light into said optical coupler to thereby be coupled into said single-mode optical fiber and further arranged to receive return light from said optical coupler comprising temperature-correcting light being at least one of scattered or reflected back to said temperature-correcting optical system, said temperature-correcting optical system being further configured to provide a reference beam of light to be combined at least partially coherently with said return light to provide an interference light, said temperature-correcting optical system further comprising a detector system arranged to detect said interference light to provide said temperature-correction signals; determining, by the one or more computer processors, at least one physical property of the particle in contact with said optical resonator using said sensor signals; and correcting said at least one physical property in temperature using said temperature calibration data and said temperature-correction signals. ### Claim 15 (depends on 14) The method according to claim 14, further comprising: performing, by the one or more computer processors, a Fourier transform of said temperature-correction signals; and performing, by the one or more computer processors, a correlation with said temperature calibration data to obtain a temperature correction of said at least one physical property of said particle in contact with said optical resonator. ### Claim 16 A software program comprising a set of instructions stored on a non-transitory computer-readable medium, the instructions when executed by one or more computer processors cause the one or more computer processors to perform a method for determining at least one physical property of a particle in contact with an optical resonator, the method comprising: receiving, by the one or more computer processors, temperature calibration data from a storage device, for at least a single-mode optical fiber and said optical resonator, said single-mode optical fiber being disposed in proximity of said optical resonator, said single-mode optical fiber being optically coupled to an optical coupler arranged to receive sensor light from a sensor optical source, said optical resonator having an optical whispering-gallery mode and being optically coupled to said single-mode optical fiber through an evanescent field to excite said optical whispering-gallery mode and to receive optical whispering-gallery output light; receiving, by the one or more computer processors, sensor signals from a sensor detection system arranged to receive and detect said optical whispering-gallery output light from said single-mode optical fiber; receiving, by the one or more computer processors, temperature-correction signals from a temperature-correcting optical system arranged to couple temperature-correcting light into said optical coupler to thereby be coupled into said single-mode optical fiber and further arranged to receive return light from said optical coupler comprising temperature-correcting light being at least one of scattered or reflected back to said temperature-correcting optical system, said temperature-correcting optical system being further configured to provide a reference beam of light to be combined at least partially coherently with said return light to provide an interference light, said temperature-correcting optical system further comprising a detector system arranged to detect said interference light to provide said temperature-correction signals; determining, by the one or more computer processors, at least one physical property of the particle in contact with said optical resonator using said sensor signals; and correcting said at least one physical property in temperature using said temperature calibration data and said temperature-correction signals. ### Claim 17 (depends on 16) The software program according to claim 16, further comprising: performing, by the one or more computer processors, a Fourier transform of said temperature-correction signals; and performing, by the one or more computer processors, a correlation with said temperature calibration data to obtain a temperature correction of said at least one physical property of said particle in contact with said optical resonator.