# US 2025/0093247 A1 · Adaptive time light scattering and electrophoretic mobility data collection techniques > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2025/0093247 A1 - Document ID: US20250093247A1 - Status: Published application - Kind: A1 - Application number: 18/889,553 - Filed: 2024-09-19 - Published: 2025-03-20 - Earliest claimed: 2023-09-19 - Assignees: Wyatt Technology Corporation - Applicants: Wyatt Technology, LLC - Inventors: Steven P. Trainoff; Cha Lee; Shivakumar Ramini - Web page: https://patentgrep.com/patent/US20250093247A1 ## CPC - G01N 15/0205: by optical means - G01N 15/0211: {Investigating a scatter or diffraction pattern} - G01N 15/0266: {with electrical classification} - G01N 15/1429: Signal processing - G01N 2015/0003: {Determining electric mobility, velocity profile, average speed or velocity of a plurality of particles} - G01N 2015/0222: {from dynamic light scattering, e.g. photon correlation spectroscopy} - G01N 2015/0277: {Average size only} - G16H 10/40: for data related to laboratory analysis, e.g. patient specimen analysis - G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q) - G16H: HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA ## Abstract The present disclosure describes a method, system, and computer program product comprising a process whereby measurement data collected by an instrument is collected adaptively until a desired relative or absolute accuracy is achieved. ## Claims ### Claim 1 A method comprising: receiving, from a data store by a computer system, a predetermined threshold related to a statistical accuracy for determining a measurement result related to a sample processed by an instrument; collecting data regarding the sample from the instrument until a standard error of a mean among an acquisition series of the data is substantially equal to the predetermined threshold; and generating the measurement result of the acquisition series of the data when the standard error is substantially equal to the predetermined threshold. ### Claim 2 (depends on 1) The method of claim 1, wherein collecting the data comprises defining each acquisition of the acquisition series on a measurement process as a function of the each acquisition integrated for an integration time. ### Claim 3 (depends on 2) The method of claim 2, wherein the measurement process generates a result including a particle size or electrophoretic mobility of the sample. ### Claim 4 (depends on 1) The method of claim 1 further comprising: calculating, by the computer system, a mean value and a standard deviation value of an acquisition of the acquisition series; calculating a relative standard error as a function of the mean value and the standard deviation value; and determining that the relative standard error is the standard error when the relative standard error is substantially equal to the predetermined threshold. ### Claim 5 (depends on 4) The method of claim 4, as a number of acquisitions increases, the mean of the acquisition series converges to a true underlying mean value and the standard deviation of the acquisition series converges to a true standard deviation of individual acquisitions. ### Claim 6 (depends on 4) The method of claim 4 further comprising: controlling the instrument to cease providing additional acquisitions for the acquisition series in response to a determination that the relative standard error is substantially equal to the predetermined threshold. ### Claim 7 (depends on 1) The method of claim 1 further comprising: providing a user-defined maximum time limit for the collective integration times of the acquisitions in the acquisition series. ### Claim 8 (depends on 1) The method of claim 1, wherein the instrument is an electrophoretic light scattering (ELS) measurement instrument and wherein the data collected from the instrument comprises electrophoretic mobility data from the ELS measurement instrument. ### Claim 9 (depends on 1) The method of claim 1, wherein the instrument is a dynamic light scattering (DLS) instrument for measuring diffusion behavior of molecules of the sample. ### Claim 10 (depends on 1) The method of claim 1, wherein the data regarding the sample is collected according to at least one collection parameter, including an integration time and a number of acquisitions for a desired sample measurement. ### Claim 11 (depends on 1) The method of claim 1, further comprising: computing the standard error of the mean computed from the acquisitions in a single measurement that is the same as a standard deviation computed between multiple measurements. ### Claim 12 (depends on 1) The method of claim 1, further comprising after the data is collected, allowing for the choice of the threshold to use or the maximum number of acquisitions to use per measurement to be adjusted after-the-fact. ### Claim 13 (depends on 1) The method of claim 1, wherein the predetermined threshold comprises a relative standard error threshold or an absolute standard error threshold. ### Claim 14 A method, comprising: programming a special-purpose computer system with a set of collection parameters including a desired statistical accuracy and a maximum number of acquisitions; collecting acquisition data for determining a measurement, the acquisition data collected according to the set of collection parameters; as each subsequence acquisition is collected, computing a standard error of the mean of all acquisitions that have been completed, wherein when a value of a current acquisition crosses a predetermined threshold related to the statistical accuracy or the maximum number of acquisitions is reached, the system returns the measurement. ### Claim 15 (depends on 14) The method of claim 14, wherein collecting the acquisition data comprises defining each acquisition of an acquisition series on a measurement process as a function of the each acquisition integrated for an integration time. ### Claim 16 (depends on 14) The method of claim 14, wherein determining the measurement comprises generates a result including a particle size or electrophoretic mobility. ### Claim 17 (depends on 14) The method of claim 14, wherein the predetermined threshold comprises a relative standard error threshold or an absolute standard error threshold. ### Claim 18 A computer program product comprising a computer readable storage medium having program instructions embodied therewith, the program instructions executable by a processor to cause the processor to perform a method comprising: receiving a predetermined threshold related to a statistical accuracy for determining a measurement result related to a sample processed by an instrument; collecting data regarding the sample from the instrument until a standard error in a mean among an acquisition series of the data is substantially equal to the predetermined threshold; and generating the measurement result of the acquisition series of the data when the standard error is substantially equal to the predetermined threshold. ### Claim 19 (depends on 18) The computer program product of claim 18, wherein the predetermined threshold comprises a relative standard error threshold or an absolute standard error threshold.