Thioamide analogues of peptide antigens
AssigneeWisconsin Alumni Research Foundation
InventorsSamuel Gellman, Rylie Morris, Ruslan Gibadullin, Jiani Niu
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Abstract
A method to make polypeptide antigens with increased resistance to enzymatic degradation and the polypeptide antigens so formed. The method includes fabricating a polypeptide analogue of a native polypeptide antigen in which at least one backbone C═O group in the native polypeptide antigen residues is replaced with a backbone C═S group.
Claims24
A method to make polypeptide antigens with increased resistance to enzymatic degradation, the method comprising fabricating a polypeptide analogue of a native polypeptide antigen in which at least one backbone C═O group in the native polypeptide antigen residues is replaced with a backbone C═S group, wherein the polypeptide analogue has an N-terminus and a C-terminus.
A non-natural polypeptide antigen with increased resistance to enzymatic degradation, the polypeptide antigen comprising from 8 to 100 residues and having an N-terminus and a C-terminus, wherein at least one residue of the polypeptide antigen has a backbone C═O group replaced with a backbone C═S group, and wherein the residue at the C-terminus has a backbone C═O group.
Dependencies are inferred from the claim text.