C7, c12, and c16 substituted neuroactive steroids and their methods of use

A compound of Formula (I):

• or a pharmaceutically acceptable salt thereof, wherein:
• both are single bonds;
• R5 is hydrogen;
• each of R2, R4, R6, R11a, and R11b is independently hydrogen, halogen, cyano, nitro, alkyl, alkenyl, alkynyl, carbocyclyl, heterocyclyl, aryl, heteroaryl, —ORA1, —SRA1, —N(RA1)2—NHC(═O)RA1, —NHC(═O)ORA1, —S(═O)RA2, —SO2RA2, or —S(═O)2ORA1, wherein each instance of RA1 is independently hydrogen, alkyl, alkenyl, alkynyl, carbocyclyl, heterocyclyl, aryl, heteroaryl, an oxygen protecting group when attached to an oxygen atom, a sulfur protecting group when attached to a sulfur atom, a nitrogen protecting group when attached to a nitrogen atom, or two RA1 groups are joined to form an heterocyclic or heteroaryl ring;
• and RA2 is alkyl, alkenyl, alkynyl, carbocyclyl, heterocyclyl, aryl, or heteroaryl;
• or R11a and R11b together form oxo;
• R3 is C1-C6 alkyl;
• R17 is alkoxy, cyano, nitro, aryl, heteroaryl, or —C(O)RB1, —C(O)CH2RB1, or —C(O)CH2CH2RB1, wherein RB1 is hydrogen, —OH, alkoxy, aryl, or heteroaryl;
• R19 is hydrogen or unsubstituted C1-C6 alkyl;
• and
• R7 is —CH3, —CH2CH3, —OH, —OCH3, or —CH2OCH3.