A 6-substituted Chiral Pure Difluoropiperidine Quinazoline Derivative And Its Preparation Method
AssigneeWeishang (Shanghai) Bio-Pharmaceutical Co., Ltd.
InventorWei ZHONG
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Abstract
The present disclosure discloses a preparation method for 6-substituted chiral pure difluoropiperidine quinazoline derivative, in particular the 6-substituted chiral pure difluoropiperidine quinazoline derivative shown in Formula (I). The preparation method provided by the present disclosure is characterized by high chiral selectivity, high yield, and good process stability, which is of great significance for further production scale-up and commercialization of said solid drugs.
Claims10
A preparation method for 6-substituted chiral pure difluoropiperidine quinazoline derivative, wherein the method comprises a step of quinazoline ring closing:
- 2-amino-benzonitrile derivative
- reacts with (E)-N,N′-bisphenylformamide derivative
- in the presence of organic solvent and glacial acetic acid to obtain 6-substituted chiral pure difluoropiperidine quinazoline derivative
- where R is Boc, oxetane, or methyl.
Dependencies are inferred from the claim text.