Soft tissue protein compositions, methods of making, and uses thereof
AssigneeAdvanced Biologics, Inc.
InventorsAmit Prakash Govil, Bryan Choi, Sahil Jalota
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Abstract
Provided herein are soluble soft tissue protein compositions that can contain one or more soft-tissue bioactive factors, methods of making the soluble soft tissue protein compositions, and methods of using the soluble soft tissue protein compositions.
Claims20
A dehydrated soluble soft tissue protein composition comprising a bioactive factor, where the dehydrated soluble soft tissue protein composition is made by a method comprising:
- harvesting soft tissue from a donor to obtain harvested soft tissue, where the soft tissue contains soft tissue cells;
- heating the harvested soft tissue to at least 20° C.;
- lysing the soft tissue cells by osmotic shock without a detergent to obtain a soft tissue cell lysate;
- isolating the soft tissue lysate from the soft tissue to yield the soluble soft tissue protein composition;
- and
- dehydrating the soluble soft tissue lysate to obtain a dehydrated soluble soft tissue protein composition.
The soluble soft tissue protein composition of claim 5, wherein the steps of washing the harvested soft tissue, heating the harvested soft tissue, and lysing soft tissue cells occur simultaneously.
Dependencies are inferred from the claim text.