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US 2025/0090694 A1Published application
Methods and systems for producing, using, and administering hyperpolarized fluids
OwnerClifford Russell Bowers, Wenbo Zhaoinventors
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Abstract
Methods of and systems for making a hyperpolarized fluid are provided, which include exposing a fluid and parahydrogen to a catalyst. The hyperpolarized fluid can be introduced to a subject. The hyperpolarized fluid can be included in methods of imaging a subject. Also provided are methods that use the hyperpolarized fluids for detecting protein-ligand interactions and for enhancing the NMR signals of biopolymers having chemically exchangeable protons.
Claims20
A system for making a hyperpolarized fluid, comprising:
- a holding vessel including a fluid and a catalyst;
- and
- a gas introduction system in communication with the holding vessel, wherein the gas introduction system is configured to introduce parahydrogen into the holding vessel by bubbling the parahydrogen into the holding vessel,
- wherein the system is configured to expose the parahydrogen, the fluid, and the catalyst to one another to form the hyperpolarized fluid.
1 more element
A system for making a hyperpolarized fluid, comprising:
- a holding vessel;
- a gas introduction system in communication with the holding vessel, wherein the gas introduction system is configured to introduce a fluid-parahydrogen mixture to the holding vessel, wherein the fluid-parahydrogen mixture includes the parahydrogen dissolved in the fluid;
- and
- a catalyst introduction system in communication with the holding vessel, wherein the catalyst introduction system is configured to introduce the catalyst to the holding vessel,
- wherein the system is configured to expose the fluid-parahydrogen mixture and the catalyst to one another in the holding vessel to form the hyperpolarized fluid.
2 more elements
A system for making a hyperpolarized fluid, comprising:
- a holding vessel including a catalyst;
- a fluid vaporization system in communication with the holding vessel, wherein the fluid vaporization system is configured to introduce a vaporized fluid to the holding vessel;
- and
- a gas introduction system in communication with the holding vessel, wherein the gas introduction system introduces parahydrogen into the holding vessel,
- wherein the system is configured to introduce the vaporized fluid and the parahydrogen to the catalyst to form the hyperpolarized fluid.
2 more elements
Dependencies are inferred from the claim text.