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US 2025/0090649 A1Published application
Influenza virus mutants and uses therefor
AssigneeFluGen, Inc.
InventorsPamuk BILSEL, Yasuko HATTA
Life of this patent
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Abstract
Disclosed herein are compositions and methods related to mutant viruses, and in particular, mutant influenza viruses. The mutant viruses disclosed herein include a mutant M2 sequence, and are useful in immunogenic compositions, e.g., as vaccines. Also disclosed herein are methods, compositions and cells for propagating the viral mutants, and methods, devices and compositions related to vaccination.
Claims22
-4. (canceled)
A recombinant influenza virus comprising a mutation in the M gene.
-15. (canceled)
A composition comprising:
- a recombinant influenza virus comprising a mutation in the M gene.
-34. (canceled)
A method for immunizing a subject, comprising:
- administering a composition comprising a recombinant influenza virus comprising mutation in the M gene, wherein the mutation in the M gene results in failure of the virus to express the M2 protein, or causes the virus to express a truncated M2 protein having the amino acid sequence of SEQ ID NO:4.
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-55. (canceled)
Dependencies are inferred from the claim text.