Method of Forming Prefabricated Units Used in the Production of Systems of Prosthetic Aortic Valve Transcatheter Implantation and a Prosthetic Aortic Valve Prefabricated Unit

A method of forming prefabricated units used in production of systems of prosthetic aortic valve transcatheter implantation with a non-thrombogenic smooth surface layer or with a porous fibrous layer constituting a scaffold for epithelium cell culture, intended for manufacturing TAVI system in form of a material made of nanofiber integrated with a stent, comprising:

• preparing between 1 and 133 stents made of a cobalt-nickel alloy with a wall thickness of 150-500 μm
• providing a first solution in a solvent DMAC,
• providing an electrospinning machine
• electrospraying a smooth layer of polycarbonate silicone is applied with use of the solution in DMAC with a concentration of 2-11% w/w. and/or by electrospinning polycarbonate urethane fiber is applied with use of the solution in DMAC with concentration of 8-20% w/w. onto a roller to obtain a first surface layer,
• applying specified speed, number of heads, thickness of capillaries, rotation speed, voltage and distance between each capillary and the roller, whereas flow on a pump administering the solution on the heads forms a layer covering the roller with thickness of approximately 1-100 μm thereafter
• forming an inner intermediate layer by electrospraying the layer of polycarbonate silicone with use of the solution in DMAC with a concentration of 2-8%/w. and/or by electrospinning the polycarbonate urethane silicone with use of the solution in DMAC with the concentration of 8-20%/w. applying specified speed, number of heads, thickness of capillaries, rotation speed, voltage and distance between each capillary and the roller, and when the thickness of the layer is approximately 5 to 100 μm, the forming is stopped, and
• placing the stents onto the formed layer, positioning their location so that the distance between each of them was 30 mm, and similarly to applying the inner intermediate layer,
• applying the inner intermediate layer on entire length of the roller, obtaining the thickness of approximately 5 to 100 μm, thereafter a final surface layer is applied similarly to the first surface layer until prefabricated units of a polymer material thickness of 50 to 250 μm is obtained.