US 2025/0085287 A1 · METHODS FOR DETECTION OF MEMBRANE BOUND GLYPICAN-3

Abstract

Embodiments provide for anti-GPC3 antibodies compositions comprising the same, and methods of using such antibodies and compositions for the prevention, diagnosis, and treatment of cancer. In one embodiment, a method for predicting a therapeutic effect of an anti-GPC3 immunotherapy on a cancer characterized in that cells of the cancer express GPC3, comprises detecting the presence of said cells in a subject via an immunohistochemical methodology, and wherein when the presence of said cells is detected, the anti-GPC3 immunotherapy is predicted to have a therapeutic effect on the cancer in the subject.

Claims42

Dependent claims

An isolated monoclonal antibody that binds glypican-3 (GPC3), wherein:

the heavy chain of the anti-GPC3 antibody comprises a complementary determining region (CDR) 1 set forth as SEQ ID NO:
6, a CDR2 set forth as SEQ ID NO:
8, and a CDR3 set forth as SEQ ID NO:
10, and the light chain of the antibody comprises a CDR1 set forth as SEQ ID NO:
13, a CDR2 set forth as SEQ ID NO:
15, and a CDR3 set forth as SEQ ID NO:
17.

4 more elements

Dependencies are inferred from the claim text.

Methods for detection of membrane bound glypican-3

Life of this patent

Methods for detection of membrane bound glypican-3

Life of this patent

Abstract

Claims42