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US 2025/0085265 A1Published application
Pharmaceutical Apparatus And Method Of Manufacturing A Patient-Tailored Pharmaceutical Tablet
AssigneeCyrus Scientific, LLC
InventorsAmin ABEDINI, Matthew Kyle DEFRESE
Life of this patent
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Abstract
A pharmaceutical apparatus is provided. In another aspect, a pharmaceutical apparatus includes a tablet press configured to compress a first powdered ingredient and a second powdered ingredient into a multi-layer pharmaceutical tablet. A further aspect employs an analytical and quality control table including at least one of a process analytical technologies (“PAT”) sensor and an imaging device. In another aspect, the analytical and quality control table further includes a weighing device configured to operate with a standard deviation between 0 and 3. In yet another aspect, the pharmaceutical apparatus utilizes a programmable controller to operate the pharmaceutical apparatus.
Claims35
A pharmaceutical apparatus comprising:
- a tablet press configured to compress a first powdered ingredient and a second powdered ingredient into a multi-layer pharmaceutical tablet;
- and
- an analytical and quality control table physically separated from the tablet press configured to receive the pharmaceutical tablet from the tablet press, the analytical and quality control table comprising at least one PAT sensor;
- the PAT sensor comprises at least one of:
- an ultraviolet-visible spectrometer, a near-infrared spectrometer, a Raman spectrometer, a fluorescence spectrometer, a refractometer, or a micro-indentation sensor;
- and
- wherein the at least one PAT sensor is configured to assist in determining a potency of a first layer with the first powdered ingredient and at least a second layer with the second powdered ingredient of the pharmaceutical tablet.
4 more elements
A pharmaceutical apparatus comprising:
- a tablet press, including a die and a punch;
- a first dosing unit configured to insert a first powdered ingredient into the die of the tablet press;
- a second dosing unit configured to insert a second powdered ingredient into the die of the tablet press;
- and
- an analytical and quality control table including a transfer mechanism and a sensor;
- wherein the punch of the tablet press is configured to compress at least one powdered ingredient in the die into at least a first layer of a pharmaceutical tablet,
- wherein the transfer mechanism is configured to transfer the pharmaceutical tablet to a position accessible by the sensor;
- wherein when the analytical and quality control table includes the sensor which is configured to assist in determining at least one of:
- hardness, water content, impurities, or a presence of polymorphs of the pharmaceutical tablet.
6 more elements
A method of manufacturing a pharmaceutical tablet, the method comprising:
- (a) receiving details of the pharmaceutical tablet order for a number of tablets at a programmable controller, the details corresponding to at least one of:
- a color of the first layer of the pharmaceutical tablet, a color of the second layer of the pharmaceutical tablet, a tablet identifier of the pharmaceutical tablet, or a maximum amount of acceptable visual defects of the pharmaceutical tablets;
- (b) controlling operation of a first dosing unit, a second dosing unit, a tablet press, an analytical and quality control platform, a sensor and an imaging camera, with the controller;
- (c) automatically determining an amount of a first powdered ingredient to be included in the pharmaceutical tablet and an amount of a second powdered ingredient to be included in the pharmaceutical tablet with the controller based at least in part on the details;
- (d) sending a signal from the controller to the first dosing unit directing the first dosing unit to insert the amount of the first powdered ingredient into a die of the tablet press;
- (e) sending a signal from the controller to the tablet press directing the tablet press to extend a punch to compress the first powdered ingredient to form the first layer of the pharmaceutical tablet;
- (f) sending a signal from the controller to the second dosing unit directing the second dosing unit to insert the amount of the second powdered ingredient into the die of the tablet press;
- (g) sending a signal from the controller to the tablet press directing the tablet press to extend the punch to compress the second powdered ingredient to form the second layer of the pharmaceutical tablet;
- (h) sending a signal from the controller to the tablet press directing the tablet press to eject the pharmaceutical tablet from the tablet press;
- (i) transferring the pharmaceutical tablet to the quality control platform;
- (j) sending a signal from the controller to the quality control platform directing the quality control platform to place the pharmaceutical tablet in a position wherein the pharmaceutical tablet is accessible by the sensor and the camera;
- (k) sending a signal from the controller to the sensor and the camera to gather data related to the pharmaceutical tablet;
- and
- (l) sending the data related to the pharmaceutical tablet from the sensor and the camera to the controller, the data assisting the controller in determining at least one of:
- potency, water content, impurities, or a presence of polymorphs of the first powdered ingredient and the second powered ingredient.
12 more elements
A method of manufacturing a pharmaceutical tablet, the method comprising:
- (a) inserting an amount of a first powdered ingredient into a die of a tablet press;
- (b) inserting an amount of a second powdered ingredient into the die of the tablet press;
- (c) compressing the first powdered ingredient and the second powdered ingredient into the pharmaceutical tablet;
- (d) transferring the pharmaceutical tablet to an analytical and quality control station which is physically separated from the tablet press and comprises at least one of:
- an ultraviolet-visible spectrometer sensor, a near-infrared spectrometer sensor, a Raman spectrometer sensor, a fluorescence spectrometer sensor, a refractometer sensor, or a micro-indentation sensor;
- and
- (e) using software, stored in non-transient memory, to automatically determine at least one of:
- potency, hardness, water content, impurities, or a presence of polymorphs of the pharmaceutical tablet, with the assistance of a signal from the sensor.
5 more elements
Dependencies are inferred from the claim text.