# US 2025/0085256 A1 · Methods and systems for ion mobility spectrometry > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2025/0085256 A1 - Document ID: US20250085256A1 - Status: Published application - Kind: A1 - Application number: 18/463,570 - Filed: 2023-09-08 - Published: 2025-03-13 - Earliest claimed: 2023-09-08 - Assignees: Analytical Detection LLC - Applicants: Analytical Detection LLC - Inventors: Andrey N. Vilkov; Joseph Adam Widjaja; Jack Albert Syage; Brent D. Goldberg - Web page: https://patentgrep.com/patent/US20250085256A1 ## CPC - G01N 27/622: Ion mobility spectrometry - G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q) ## Abstract An example ion mobility spectrometry system includes a drift chamber, an ion detector, a thermal sensor, and processing circuitry. The drift chamber is configured to receive an ionized sample and an ionized calibrant. The ion detector is configured to generate a drift signal in response to detecting drifted ions at a predetermined position along the drift chamber. The thermal sensor is configured to generate a temperature signal indicative of a temperature of the drift chamber. The processing circuitry is configured to determine, based on the temperature signal, a mobility relation for a target species; determine, based on the drift signal, calibrant and sample drift times; determine, based on the mobility relation and the calibrant drift time, a target drift time; and detect the target species in the ionized sample by comparing the sample drift time with the target drift time. ## Claims ### Claim 1 An ion mobility spectrometry system comprising: a drift chamber configured to receive an ionized sample and an ionized calibrant; an ion detector configured to generate a drift signal in response to detecting drifted ions at a predetermined position along the drift chamber; a thermal sensor configured to generate a temperature signal indicative of a temperature of the drift chamber; and processing circuitry configured to: determine, based on the temperature signal, a mobility relation for a target species with respect to the ionized calibrant; determine, based on the drift signal, a calibrant drift time and a sample drift time; determine, based on the mobility relation and the calibrant drift time, a target drift time for the target species; and detect the target species in the ionized sample by comparing the sample drift time with the target drift time. ### Claim 2 (depends on 1) The system of claim 1, wherein to determine a presence of the target species the processing circuitry is further configured to determine that the sample drift time is within a predetermined drift time range comprising the target drift time. ### Claim 3 (depends on 1) The system of claim 1, wherein the processing circuitry is further configured to generate an output indicative of the presence of the target species. ### Claim 4 (depends on 1) The system of claim 1, wherein the mobility relation is a linear function of the calibrant drift time. ### Claim 5 (depends on 1) The system of claim 1, further comprising an ionization chamber configured to ionize a sample volume into the ionized sample and a calibrant volume into the ionized calibrant, wherein the drift chamber is between the ion detector and the ionization chamber. ### Claim 6 (depends on 5) The system of claim 5, further comprising a sample chamber configured to fluidize an analyte sample to generate the sample volume. ### Claim 7 (depends on 5) The system of claim 5, further comprising a calibrant chamber configured to fluidize a calibrant composition to generate the calibrant volume. ### Claim 8 (depends on 1) A portable spectrometry device comprising a handheld housing, the handheld housing comprising the ion mobility spectrometry system of claim 1. ### Claim 9 A method for ion mobility spectrometry, the method comprising: introducing an ionized sample and an ionized calibrant in a drift chamber; generating, by an ion detector, a drift signal in response to detecting drifted ions at a predetermined position along the drift chamber; generating, by a thermal sensor, a temperature signal indicative of a temperature of the drift chamber; and by processing circuitry: determining, based on the temperature signal, a mobility relation for a target species with respect to the ionized calibrant; determining, based on the drift signal, a calibrant drift time and a sample drift time; determining, based on the mobility relation and the calibrant drift time, a target drift time for the target species; and detecting the target species in the ionized sample by comparing the sample drift time with the target drift time. ### Claim 10 (depends on 9) The method of claim 9, wherein detecting the target species comprises determining, by the processing circuitry, a presence of the target species in response to determining that the sample drift time is within a predetermined drift time range comprising the target drift time. ### Claim 11 (depends on 10) The method of claim 10, further comprising, by the processing circuitry, generating an output indicative of the presence of the target species, wherein the output comprises at least one of a digital signal, an audio signal, or a display signal. ### Claim 12 (depends on 9) The method of claim 9, wherein the drift temperature is at room temperature. ### Claim 13 (depends on 9) The method of claim 9, wherein the mobility relation is a linear function of the calibrant drift time. ### Claim 14 (depends on 9) The method of claim 9, further comprising ionizing a sample volume into the ionized sample and a calibrant volume into the ionized calibrant. ### Claim 15 (depends on 14) The method of claim 14, further comprising fluidizing a calibrant composition to generate the calibrant volume. ### Claim 16 (depends on 15) The method of claim 15, wherein the calibrant composition comprises at least one of dipropylene glycol monomethyl ether (DPMGE) or salicylic acid. ### Claim 17 (depends on 14) The method of claim 14, further comprising reacting a reagent volume with the calibrant volume. ### Claim 18 (depends on 17) The method of claim 17, further comprising fluidizing a reagent composition to generate the calibrant volume. ### Claim 19 (depends on 18) The method of claim 18, wherein the reagent composition comprises dipropylene glycol monomethyl ether (DPMGE). ### Claim 20 Non-transitory computer-readable media comprising instructions that, when executed, cause processing circuitry to: determine, based on a drift signal received from an ion detector in response to detecting drifted ions at a predetermined position along a drift chamber, a calibrant drift time of an ionized calibrant and a sample drift time of an ionized sample in the drift chamber; determine, based on a temperature signal indicative of a temperature of the drift chamber received from a thermal sensor, a mobility relation for a target species with respect to the ionized calibrant; determine, based on the mobility relation and the calibrant drift time, a target drift time for the target species; and detect the target species in the ionized sample by comparing the sample drift time with the target drift time.