Formate dehydrogenase variants and methods of use
AssigneeGenomatica, Inc.
InventorsAmit Mahendra Shah, Justin Robert Colquitt, Michael Gregory Napolitano, Nathan Schmidt, Pichet Praveschotinunt, Joseph Roy Warner
Life of this patent
Estimating the term…
Abstract
The disclosure provides polypeptides and encoding nucleic acids of engineered formate dehydrogenases. The disclosure also provides cells expressing an engineered formate dehydrogenase. The disclosure further provides methods for producing a bioderived compound comprising culturing cells expressing an engineered formate dehydrogenase. Where the engineered formate dehydrogenase is capable of catalyzing a conversion.
Claims58
An engineered formate dehydrogenase comprising a variant of amino acid sequence SEQ ID NO:
- 1 or SEQ ID NO:
- 2 or a functional fragment thereof, wherein the engineered formate dehydrogenase comprises one or more alterations at a position described in TABLE 6 and/or TABLE 7.
An engineered formate dehydrogenase comprising a variant of an amino acid sequence selected from any one of SEQ ID NOs:
- 3-24, wherein the engineered formate dehydrogenase comprises one or more alterations at a position corresponding to a position described in TABLE 6 and/or TABLE 7.
Dependencies are inferred from the claim text.