Inst for poliomyelitis, chumakov fed sci ctr r&d immune&biological prods, russian acad of sciences

A sampler idi adapted in an operational state for connection to a bioreactor filled with a cell culture aqueous solution, the sampler comprising:

• a conduit having a first end adapted for connection to a port of the bioreactor, the port being intended for collecting samples of the cell culture aqueous solution, and a second free end opposite the first end,
• a hydrophobic air filter disposed within the conduit between the first end and the second free end,
• the hydrophobic air filter being adapted for a free egress of air from the conduit to an exterior through the second free end under an effect of a pressure differential between the first end and the second free end, when the conduit of the sampler is filled, in the operational state, with the cell culture aqueous solution from the bioreactor,
• the hydrophobic air filter being impermeable to the cell culture aqueous solution, and
• a transparent solid container incorporated into the conduit between the first end and the hydrophobic air filter, the transparent solid container being adapted for filling with the cell culture aqueous solution and for a contactless analysis of the cell culture aqueous solution with the help of an analyzer.