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US 2025/0084303 A1Published application
Complexes and Ligands
AssigneeThe General Hospital Corporation
InventorsRalph Mazitschek, N. Connor Payne, Alena Kalyakina
Life of this patent
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Abstract
The present application provides ligands and fluorescent or luminescent complexes comprising these ligands.
Claims25
1-289. (canceled)
A compound of Formula (IIIf):
- or a pharmaceutically acceptable salt thereof, wherein:
- Y is selected from C1-6 alkylene, C2-6 alkenylene, and C2-6 alkynylene;
- x is an integer from 0 to 100;
- wherein if x is 0 then L is a bond;
- each L is independently selected from C1-3 alkylene, C2-4 alkenylene, C2-4 alkynylene, C1-3 alkylene-O—, —O—C1-3 alkylene, phenylene, —C(O)NH—, —NHC(O)—, —C(O)O—, and —OC(O)—;
- each X1 is independently selected from halo, NO2, CN, N3, C1-6 alkyl, C1-6 alkoxy, C2-6 alkenyl, C2-6 alkynyl, C6-10 aryl, and 5-14 membered heteroaryl, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C6-10 aryl, and 5-14 membered heteroaryl are each optionally substituted with 1, 2, or 3 substituents independently selected from halo, OH, SH, NH2, C1-3 alkylamino, di(C1-3 alkyl)amino, NO2, CN, C(O)OH, C1-3 alkoxy, C1-3 haloalkoxy, and N3;
- and
- each R1 is independently selected from H, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with 1, 2, or 3 substituents independently selected from halo, OH, SH, NH2, C1-3 alkylamino, di(C1-3 alkyl)amino, NO2, CN, C(O)OH, C1-3 alkoxy, C1-3 haloalkoxy, and N3.
5 more elements
Dependencies are inferred from the claim text.