Macrocyclic amide compounds and application thereof

A compound of formula (V) or a pharmaceutically acceptable salt thereof,

• wherein
• T1 and T2 are each independently selected from N and CH;
• T3 is selected from N and CRe;
• T4 is selected from N and CRf;
• L1 is selected from —O— and —NH—;
• L2 is selected from —CH2— and —C(═O)—;
• L3 is selected from —O—, —NH— and —CH2—;
• L4 is selected from —C1-3 alkyl-, —P(═O)(Ra)—, —S(═O)2—, —S(═O)(═NRc)— and —N═S(═O)(Rb)—;
• L5 is selected from
• C3-5 cycloalkyl, 4- to 5-membered heterocycloalkyl, —CH2—C5-6 cycloalkyl-, —CH2—C5-6 cycloalkyl-CH2—, —CH2-5- to 6-membered heterocycloalkyl and —CH2-5- to 6-membered heterocycloalkyl-CH2—;
• R1 is absent, R2 is selected from CH3 and cyclopropyl;
• alternatively, R1 and R2 are taken together with the atoms to which they are attached to form a 5-membered heteroaryl;
• R3 is selected from C1-3 alkyl, C3-5 cycloalkyl and -piperazinyl-methyl;
• R4 is selected from C1-3 alkyl, wherein the C1-3 alkyl is optionally substituted with 1, 2 or 3 Rd;
• R5 is CH3, wherein the CH3 is optionally substituted with 1, 2 or 3 halogens;
• R6 is selected from H and CH3, wherein the CH3 is optionally substituted with 1, 2 or 3 halogens;
• R7 is selected from H and CH3, wherein the CH3 is optionally substituted with 1, 2 or 3 halogens;
• alternatively, R5 and R6 are taken together with the atom to which they are attached to form a cyclopropyl;
• Ra is selected from C1-3 alkyl and C3-5 cycloalkyl;
• Rb is selected from C1-3 alkyl;
• Rc is selected from H and C1-3 alkyl;
• alternatively, Ra and R3 are taken together with the atom to which they are attached to form a 5- to 6-membered heterocycloalkyl, wherein the 5- to 6-membered heterocycloalkyl is optionally substituted with 1 or 2 CH3;
• alternatively, Rb and R3 are taken together with the atoms to which they are attached to form a 5- to 11-membered heterocycloalkyl, wherein the 5- to 11-membered heterocycloalkyl is optionally substituted with 1 or 2 Rg;
• alternatively, Rc and R3 are taken together with the atoms to which they are attached to form a 5- to 6-membered heterocycloalkyl, wherein the 5- to 6-membered heterocycloalkyl is optionally substituted with 1 or 2 CH3;
• Rd is selected from halogen and C1-3 alkylamino;
• Re is selected from H, F, Cl, Br, I and CN;
• Rf is selected from H, F, Cl, Br, I and CN;
• Rg is selected from CH3 and 4- to 6-membered heterocycloalkyl, wherein the 4- to 6-membered heterocycloalkyl is optionally substituted with 1 or 2 CH3;
• provided that, when L1 is —O—, L2 is —CH2—, L3 is —CH2—, L4 is —CH2—, and R3 is -piperazinyl-methyl, then at least one of T1 and T2 is N, alternatively, R1 and R2 are taken together with the atoms to which they are attached to form a 5-membered heteroaryl group.